Association between TNF-alpha (-308 A/G,-238 A/G,-857 C/T) polymorphisms and responsiveness to TNF-alpha blockers in spondyloarthropathy, psoriasis and Crohn's disease: a meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Song, Gwan Gyu | - |
dc.contributor.author | Seo, Young Ho | - |
dc.contributor.author | Kim, Jae-Hoon | - |
dc.contributor.author | Choi, Sung Jae | - |
dc.contributor.author | Ji, Jong Dae | - |
dc.contributor.author | Lee, Young Ho | - |
dc.date.accessioned | 2021-09-05T01:16:44Z | - |
dc.date.available | 2021-09-05T01:16:44Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1462-2416 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/96358 | - |
dc.description.abstract | Aim: The aim of this study is to investigate whether TNF-alpha polymorphisms are associated with the responsiveness to anti-TNF-alpha therapy in patients with spondyloarthropathy, psoriasis, and Crohn's disease. Methods: We conducted a meta-analysis on the association between the TNF-alpha polymorphisms and responsiveness of patients. Results: The meta-analysis indicated an association between the TNF-alpha -308 G allele (OR = 2.005; 95% CI: 1.417-2.838; p = 8.6 x 10-5), TNF-alpha -238 G allele (OR = 2.196; 95% CI: 1161-4.154; p = 0.016), and TNF-alpha -857 C allele (OR = 1.779; 95% CI: 1.130-2.802; p = 0.013) and response to TNF-alpha blockers in Caucasians. Conclusion: Individuals carrying the TNF-(omega) over bar -308 G, -238 G, or -857 C common alleles show better responses to TNF-alpha blockers than those with minor alleles in Caucasians. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | FUTURE MEDICINE LTD | - |
dc.subject | TUMOR-NECROSIS-FACTOR | - |
dc.subject | INFLAMMATORY-BOWEL-DISEASE | - |
dc.subject | RHEUMATOID-ARTHRITIS | - |
dc.subject | GENE POLYMORPHISMS | - |
dc.subject | THERAPEUTIC RESPONSE | - |
dc.subject | PROMOTER | - |
dc.subject | INFLIXIMAB | - |
dc.subject | ALLELE | - |
dc.subject | SUSCEPTIBILITY | - |
dc.subject | PREDICTION | - |
dc.title | Association between TNF-alpha (-308 A/G,-238 A/G,-857 C/T) polymorphisms and responsiveness to TNF-alpha blockers in spondyloarthropathy, psoriasis and Crohn's disease: a meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.contributor.affiliatedAuthor | Choi, Sung Jae | - |
dc.contributor.affiliatedAuthor | Ji, Jong Dae | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.identifier.doi | 10.2217/PGS.15.90 | - |
dc.identifier.scopusid | 2-s2.0-84941659989 | - |
dc.identifier.wosid | 000361142500009 | - |
dc.identifier.bibliographicCitation | PHARMACOGENOMICS, v.16, no.12, pp.1427 - 1437 | - |
dc.relation.isPartOf | PHARMACOGENOMICS | - |
dc.citation.title | PHARMACOGENOMICS | - |
dc.citation.volume | 16 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1427 | - |
dc.citation.endPage | 1437 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | TUMOR-NECROSIS-FACTOR | - |
dc.subject.keywordPlus | INFLAMMATORY-BOWEL-DISEASE | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | GENE POLYMORPHISMS | - |
dc.subject.keywordPlus | THERAPEUTIC RESPONSE | - |
dc.subject.keywordPlus | PROMOTER | - |
dc.subject.keywordPlus | INFLIXIMAB | - |
dc.subject.keywordPlus | ALLELE | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
dc.subject.keywordPlus | PREDICTION | - |
dc.subject.keywordAuthor | psoriasis | - |
dc.subject.keywordAuthor | responsiveness | - |
dc.subject.keywordAuthor | spondyloarthropathy | - |
dc.subject.keywordAuthor | TNF-alpha inhibitors | - |
dc.subject.keywordAuthor | TNF-alpha polymorphism | - |
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