Evaluation of silica nanoparticle toxicity after topical exposure for 90 days
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ryu, Hwa Jung | - |
dc.contributor.author | Seong, Nak-Won | - |
dc.contributor.author | So, Byoung Joon | - |
dc.contributor.author | Seo, Heung-Sik | - |
dc.contributor.author | Kim, Jun-Ho | - |
dc.contributor.author | Hong, Jeong-Sup | - |
dc.contributor.author | Park, Myeong-Kyu | - |
dc.contributor.author | Kim, Min-Seok | - |
dc.contributor.author | Kim, Yu-Ri | - |
dc.contributor.author | Cho, Kyu-Bong | - |
dc.contributor.author | Seo, Mu Yeb | - |
dc.contributor.author | Kim, Meyoung-Kon | - |
dc.contributor.author | Maeng, Eun Ho | - |
dc.contributor.author | Son, Sang Wook | - |
dc.date.accessioned | 2021-09-05T02:00:04Z | - |
dc.date.available | 2021-09-05T02:00:04Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-12-15 | - |
dc.identifier.issn | 1176-9114 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/96472 | - |
dc.description.abstract | Silica is a very common material that can be found in both crystalline and amorphous forms. Well-known toxicities of the lung can occur after exposure to the crystalline form of silica. However, the toxicities of the amorphous form of silica have not been thoroughly studied. The majority of in vivo studies of amorphous silica nanoparticles (NPs) were performed using an inhalation exposure method. Since silica NPs can be commonly administered through the skin, a study of dermal silica toxicity was necessary to determine any harmful effects from dermal exposures. The present study focused on the results of systemic toxicity after applying 20 nm colloidal silica NPs on rat skin for 90 days, in accordance with the Organization for Economic Cooperation and Development test guideline 411 with a good laboratory practice system. Unlike the inhalation route or gastrointestinal route, the contact of silica NPs through skin did not result in any toxicity or any change in internal organs up to a dose of 2,000 mg/kg in rats. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | DOVE MEDICAL PRESS LTD | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | COLLOIDAL SILICA | - |
dc.subject | CYTOTOXICITY | - |
dc.subject | GENOTOXICITY | - |
dc.subject | RESPONSES | - |
dc.subject | SIZE | - |
dc.title | Evaluation of silica nanoparticle toxicity after topical exposure for 90 days | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ryu, Hwa Jung | - |
dc.contributor.affiliatedAuthor | Kim, Meyoung-Kon | - |
dc.contributor.affiliatedAuthor | Son, Sang Wook | - |
dc.identifier.doi | 10.2147/IJN.S57929 | - |
dc.identifier.scopusid | 2-s2.0-84937902968 | - |
dc.identifier.wosid | 000346443200012 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF NANOMEDICINE, v.9, pp.127 - 136 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF NANOMEDICINE | - |
dc.citation.title | INTERNATIONAL JOURNAL OF NANOMEDICINE | - |
dc.citation.volume | 9 | - |
dc.citation.startPage | 127 | - |
dc.citation.endPage | 136 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | COLLOIDAL SILICA | - |
dc.subject.keywordPlus | CYTOTOXICITY | - |
dc.subject.keywordPlus | GENOTOXICITY | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | SIZE | - |
dc.subject.keywordAuthor | silica nanoparticles | - |
dc.subject.keywordAuthor | toxicity | - |
dc.subject.keywordAuthor | dermal route | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.