Early biomarkers of doxorubicin-induced heart injury in a mouse model
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Desai, Varsha G. | - |
dc.contributor.author | Kwekel, Joshua C. | - |
dc.contributor.author | Vijay, Vikrant | - |
dc.contributor.author | Moland, Carrie L. | - |
dc.contributor.author | Herman, Eugene H. | - |
dc.contributor.author | Lee, Taewon | - |
dc.contributor.author | Han, Tao | - |
dc.contributor.author | Lewis, Sherry M. | - |
dc.contributor.author | Davis, Kelly J. | - |
dc.contributor.author | Muskhelishvili, Levan | - |
dc.contributor.author | Kerr, Susan | - |
dc.contributor.author | Fuscoe, James C. | - |
dc.date.accessioned | 2021-09-05T02:16:50Z | - |
dc.date.available | 2021-09-05T02:16:50Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-12-01 | - |
dc.identifier.issn | 0041-008X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/96544 | - |
dc.description.abstract | Cardiac troponins, which are used as myocardial injury markers, are released in plasma only after tissue damage has occurred. Therefore, there is a need for identification of biomarkers of earlier events in cardiac injury to limit the extent of damage. To accomplish this, expression profiling of 1179 unique microRNAs (miRNAs) was performed in a chronic cardiotoxicity mouse model developed in our laboratory. Male B6C3F(1) mice were injected intravenously with 3 mg/kg doxorubicin (DOX; an anti-cancer drug), or saline once a week for 2, 3, 4, 6, and 8 weeks, resulting in cumulative DOX doses of 6, 9, 12, 18, and 24 mg/kg, respectively. Mice were euthanized a week after the last dose. Cardiac injury was evidenced in mice exposed to 18 mg/kg and higher cumulative DOX dose whereas examination of hearts by light microscopy revealed cardiac lesions at 24 mg/kg DOX. Also, 24 miRNAs were differentially expressed in mouse hearts, with the expression of 1, 1, 2, 8, and 21 miRNAs altered at 6, 9, 12, 18, and 24 mg/kg DOX, respectively. A pro-apoptotic miR-34a was the only miRNA that was upregulated at all cumulative DOX doses and showed a significant dose-related response. Up-regulation of miR-34a at 6 mg/kg DOX may suggest apoptosis as an early molecular change in the hearts of DOX-treated mice. At 12 mg/kg DOX, up-regulation of miR-34a was associated with down-regulation of hypertrophy-related miR-150; changes observed before cardiac injury. These findings may lead to the development of biomarkers of earlier events in DOX-induced cardiotoxicity that occur before the release of cardiac troponins. Published by Elsevier Inc. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | CARDIAC TROPONIN-T | - |
dc.subject | MYOCARDIAL-INFARCTION | - |
dc.subject | INDUCED CARDIOTOXICITY | - |
dc.subject | CARDIOVASCULAR-DISEASE | - |
dc.subject | INDUCED CARDIOMYOPATHY | - |
dc.subject | MOLECULAR-MECHANISMS | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | MUSCLE CELLS | - |
dc.subject | MICRORNAS | - |
dc.subject | FAILURE | - |
dc.title | Early biomarkers of doxorubicin-induced heart injury in a mouse model | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Taewon | - |
dc.identifier.doi | 10.1016/j.taap.2014.10.006 | - |
dc.identifier.scopusid | 2-s2.0-84912071171 | - |
dc.identifier.wosid | 000346227000008 | - |
dc.identifier.bibliographicCitation | TOXICOLOGY AND APPLIED PHARMACOLOGY, v.281, no.2, pp.221 - 229 | - |
dc.relation.isPartOf | TOXICOLOGY AND APPLIED PHARMACOLOGY | - |
dc.citation.title | TOXICOLOGY AND APPLIED PHARMACOLOGY | - |
dc.citation.volume | 281 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 221 | - |
dc.citation.endPage | 229 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.subject.keywordPlus | CARDIAC TROPONIN-T | - |
dc.subject.keywordPlus | MYOCARDIAL-INFARCTION | - |
dc.subject.keywordPlus | INDUCED CARDIOTOXICITY | - |
dc.subject.keywordPlus | CARDIOVASCULAR-DISEASE | - |
dc.subject.keywordPlus | INDUCED CARDIOMYOPATHY | - |
dc.subject.keywordPlus | MOLECULAR-MECHANISMS | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | MUSCLE CELLS | - |
dc.subject.keywordPlus | MICRORNAS | - |
dc.subject.keywordPlus | FAILURE | - |
dc.subject.keywordAuthor | Doxorubicin | - |
dc.subject.keywordAuthor | Heart | - |
dc.subject.keywordAuthor | MicroRNA profiling | - |
dc.subject.keywordAuthor | Biomarker | - |
dc.subject.keywordAuthor | Mouse | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.