Pseudomonas aeruginosa-induced IL-1 beta Production is Inhibited by Sophora flavescens via the NF-kappa B/inflammasome Pathways
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jung-Loon | - |
dc.contributor.author | Shin, Heesung | - |
dc.contributor.author | Kim, Yong-Jae | - |
dc.contributor.author | Pae, Se-Hwan | - |
dc.contributor.author | Jin, Shouguang | - |
dc.contributor.author | Ha, Un-Hwan | - |
dc.date.accessioned | 2021-09-05T02:19:31Z | - |
dc.date.available | 2021-09-05T02:19:31Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-12 | - |
dc.identifier.issn | 1225-8873 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/96563 | - |
dc.description.abstract | The proinflammatory cytokine interleukin-1 beta plays an important role in protecting the host against airway infection; however, it can also trigger a massive influx of neutrophils into the airways, causing tissue damage. Anti-inflammatory treatments are particularly in demand for patients suffering from chronic inflammatory diseases. Sophora flavescens is a traditional herbal medicine used to reduce inflammation, but no study has examined its ability to block IL-beta production. Here, we show that S. flavescens reduced the Pseudomonas aeruginosa-induced expression of IL-1 beta by lung epithelial cells and macrophages. S. flavescens was also effective at reducing IL-1 beta production induced by either Staphylococcus aureus or phorbol 1 2-myristate 13-acetate, indicating that the effect is generalizable to diverse inflammatory stimuli. In addition, S. flavescens blocked the phosphorylafion of IKK alpha/beta, key upstream kinases involved in the degradation of I kappa B alpha, and the cleavage of caspase-1, a key component of the inflammasome. Thus, this study demonstrates that S. flavescens exerts its anti-inflammatory effects by blocking P. aeruginosa-mediated NF-kappa B/inflammasome activation and the subsequent production of IL-1 beta. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MICROBIOLOGICAL SOCIETY KOREA | - |
dc.subject | SIGNALING PATHWAYS | - |
dc.subject | EPITHELIAL-CELLS | - |
dc.subject | INTERLEUKIN-1 | - |
dc.subject | INFLAMMATION | - |
dc.subject | EXPRESSION | - |
dc.subject | RECEPTOR | - |
dc.subject | DISEASE | - |
dc.subject | PROLIFERATION | - |
dc.subject | INFECTIONS | - |
dc.subject | FLAVONOIDS | - |
dc.title | Pseudomonas aeruginosa-induced IL-1 beta Production is Inhibited by Sophora flavescens via the NF-kappa B/inflammasome Pathways | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Pae, Se-Hwan | - |
dc.contributor.affiliatedAuthor | Ha, Un-Hwan | - |
dc.identifier.doi | 10.1007/s12275-014-4512-3 | - |
dc.identifier.scopusid | 2-s2.0-84916625155 | - |
dc.identifier.wosid | 000345554000010 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MICROBIOLOGY, v.52, no.12, pp.1044 - 1049 | - |
dc.relation.isPartOf | JOURNAL OF MICROBIOLOGY | - |
dc.citation.title | JOURNAL OF MICROBIOLOGY | - |
dc.citation.volume | 52 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1044 | - |
dc.citation.endPage | 1049 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001928912 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | INTERLEUKIN-1 | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | INFECTIONS | - |
dc.subject.keywordPlus | FLAVONOIDS | - |
dc.subject.keywordAuthor | IL-1 beta | - |
dc.subject.keywordAuthor | inflammasome | - |
dc.subject.keywordAuthor | Pseudomonas aeruginosa | - |
dc.subject.keywordAuthor | Sophora flavescens | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.