Long-acting anticholinergic agents in patients with uncontrolled asthma: a systematic review and meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Lee, S. W. | - |
dc.contributor.author | Kim, H. J. | - |
dc.contributor.author | Yoo, K. H. | - |
dc.contributor.author | Park, Y. B. | - |
dc.contributor.author | Park, J-Y. | - |
dc.contributor.author | Jung, J. Y. | - |
dc.contributor.author | Moon, J-Y. | - |
dc.contributor.author | Byun, M. K. | - |
dc.contributor.author | Kim, S. W. | - |
dc.contributor.author | Kim, Y. H. | - |
dc.date.accessioned | 2021-09-05T02:20:37Z | - |
dc.date.available | 2021-09-05T02:20:37Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-12 | - |
dc.identifier.issn | 1027-3719 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/96565 | - |
dc.description.abstract | SETTING: A novel effective treatment is necessary for severe asthma. OBJECTIVE: To review clinical trials examining the role of tiotropium in patients with poorly controlled asthma despite inhaled corticosteroid use with or without long-acting beta(2)-agonists. DESIGN: A computerised search of electronic databases (Medline, EMBASE and Cochrane Central Register) was performed. Randomised controlled trials of at least a 4-week treatment duration with findings published in English were included. RESULTS: Five studies involving 1635 patients were analysed. Compared with a placebo or a double dose of inhaled corticosteroids, the addition of tiotropium increased mean trough and peak forced expiratory volume in 1 second by 97 ml (95%Cl 71-122) and 103 ml (95%CI 42-163), respectively. The mean differences in morning peak expiratory flow were 19.2 I/min (95%CI 11.8-26.6). Tiotropium also reduced the risk of severe acute exacerbation (OR 0.73, 95%CI 0.56-0.96) and improved Asthma Quality-of-Life Questionnaire score significantly by 0.10 (95 %Cl 0.04-0.16). There were no differences in serious adverse events. CONCLUSION: The addition of tiotropium may be beneficial for patients with poorly controlled asthma, although exacerbation or safety issues should be clarified in long-term trials before its wide use in asthma. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D) | - |
dc.subject | IPRATROPIUM BROMIDE | - |
dc.subject | LUNG-FUNCTION | - |
dc.subject | TIOTROPIUM | - |
dc.subject | SALBUTAMOL | - |
dc.subject | SALMETEROL | - |
dc.subject | THERAPY | - |
dc.subject | ADULTS | - |
dc.subject | ACETYLCHOLINE | - |
dc.subject | FLUTICASONE | - |
dc.subject | COMBINATION | - |
dc.title | Long-acting anticholinergic agents in patients with uncontrolled asthma: a systematic review and meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, H. J. | - |
dc.identifier.doi | 10.5588/ijtld.14.0275 | - |
dc.identifier.scopusid | 2-s2.0-84911377328 | - |
dc.identifier.wosid | 000345256800008 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, v.18, no.12, pp.1421 - 1430 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE | - |
dc.citation.title | INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE | - |
dc.citation.volume | 18 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1421 | - |
dc.citation.endPage | 1430 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.subject.keywordPlus | IPRATROPIUM BROMIDE | - |
dc.subject.keywordPlus | LUNG-FUNCTION | - |
dc.subject.keywordPlus | TIOTROPIUM | - |
dc.subject.keywordPlus | SALBUTAMOL | - |
dc.subject.keywordPlus | SALMETEROL | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | ADULTS | - |
dc.subject.keywordPlus | ACETYLCHOLINE | - |
dc.subject.keywordPlus | FLUTICASONE | - |
dc.subject.keywordPlus | COMBINATION | - |
dc.subject.keywordAuthor | asthma | - |
dc.subject.keywordAuthor | tiotropium | - |
dc.subject.keywordAuthor | anticholinergics | - |
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