Egr-1 is a key regulator of IL-17A-induced psoriasin upregulation in psoriasis
DC Field | Value | Language |
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dc.contributor.author | Jeong, Sang Hoon | - |
dc.contributor.author | Kim, Hee Joo | - |
dc.contributor.author | Jang, Yeonsue | - |
dc.contributor.author | Ryu, Woo In | - |
dc.contributor.author | Lee, Hana | - |
dc.contributor.author | Kim, Jin Hee | - |
dc.contributor.author | Bae, Hyun Cheol | - |
dc.contributor.author | Choi, Jae Eun | - |
dc.contributor.author | Kye, Young Chul | - |
dc.contributor.author | Son, Sang Wook | - |
dc.date.accessioned | 2021-09-05T02:22:24Z | - |
dc.date.available | 2021-09-05T02:22:24Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-12 | - |
dc.identifier.issn | 0906-6705 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/96578 | - |
dc.description.abstract | The early growth response (Egr)-1 is a transcriptional factor which plays an important role in the regulation of cell growth, differentiation, cell survival and immune responses. Emerging evidences including our data demonstrate that the Egr-1 expression is up-regulated in the psoriatic skin lesions. The purpose of this study was to investigate the significance and regulatory mechanism of Egr-1 in the pathogenesis of psoriasis. Through microarray analysis, we found out that psoriasin (S100A7) expression was increased in the Egr-1 overexpressed cells. Our results showed that IL-17A increased Egr-1 expression in the skin of psoriatic patients and cultured human keratinocytes. We then investigated activation of mitogen-activated protein kinase as an upstream signal regulator of Egr-1 expression. IL-17A-induced Egr-1 expression was suppressed by ERK inhibitor. In addition, IL-17A induced psoriasin expression in cultured keratinocytes and the skin of IL-17A intradermally injected mouse. IL-17A-mediated psoriasin upregulation was reduced after treatment of small interfering RNAs against Egr-1. Furthermore, the results of chromatin immunoprecipitation assays demonstrated that Egr-1 directly binds the psoriasin promoter. Our findings present a novel signalling mechanism by which IL-17A can induce the Egr-1-dependent psoriasin expression via the ERK pathway in human keratinocytes. This study suggests that Egr-1 may be a novel and important modulator in IL-17A-mediated immune response in psoriasis. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | ACTIVATED PROTEIN-KINASES | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | ATOPIC-DERMATITIS | - |
dc.subject | TNF-ALPHA | - |
dc.subject | ENHANCED EXPRESSION | - |
dc.subject | S100A7 PSORIASIN | - |
dc.subject | TH17 CYTOKINES | - |
dc.subject | P38 MAPK | - |
dc.subject | T-CELLS | - |
dc.subject | SKIN | - |
dc.title | Egr-1 is a key regulator of IL-17A-induced psoriasin upregulation in psoriasis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kye, Young Chul | - |
dc.contributor.affiliatedAuthor | Son, Sang Wook | - |
dc.identifier.doi | 10.1111/exd.12554 | - |
dc.identifier.scopusid | 2-s2.0-84913554948 | - |
dc.identifier.wosid | 000345694500007 | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL DERMATOLOGY, v.23, no.12, pp.890 - 895 | - |
dc.relation.isPartOf | EXPERIMENTAL DERMATOLOGY | - |
dc.citation.title | EXPERIMENTAL DERMATOLOGY | - |
dc.citation.volume | 23 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 890 | - |
dc.citation.endPage | 895 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Dermatology | - |
dc.relation.journalWebOfScienceCategory | Dermatology | - |
dc.subject.keywordPlus | ACTIVATED PROTEIN-KINASES | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | ATOPIC-DERMATITIS | - |
dc.subject.keywordPlus | TNF-ALPHA | - |
dc.subject.keywordPlus | ENHANCED EXPRESSION | - |
dc.subject.keywordPlus | S100A7 PSORIASIN | - |
dc.subject.keywordPlus | TH17 CYTOKINES | - |
dc.subject.keywordPlus | P38 MAPK | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | SKIN | - |
dc.subject.keywordAuthor | Egr-1 | - |
dc.subject.keywordAuthor | IL-17A | - |
dc.subject.keywordAuthor | keratinocytes | - |
dc.subject.keywordAuthor | psoriasin | - |
dc.subject.keywordAuthor | psoriasis | - |
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