CIIA negatively regulates neuronal cell death induced by oxygen-glucose deprivation and reoxygenation
DC Field | Value | Language |
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dc.contributor.author | Hwang, Sang Gil | - |
dc.contributor.author | Shim, Jaekyung | - |
dc.contributor.author | Choi, Eui-Ju | - |
dc.date.accessioned | 2021-09-05T02:36:31Z | - |
dc.date.available | 2021-09-05T02:36:31Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-12 | - |
dc.identifier.issn | 0300-8177 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/96672 | - |
dc.description.abstract | Brain ischemia causes neuronal injury leading to stroke and other related brain diseases. However, the precise mechanism of the ischemia-induced neuronal death remains unclear yet. In this study, we showed that CIIA suppressed neuronal cell death induced by oxygen and glucose deprivation followed by reoxygenation (OGD/R), which mimics ischemia and reperfusion in vivo, in neuroblastoma cell lines as well as primary cortical neurons. Furthermore, CIIA inhibited the OGD/R-induced stimulation of apoptosis signal-regulating kinase 1 (ASK1) and its downstream kinases including c-Jun amino-terminal kinase and p38 kinase, concomitantly blocking ASK1 homo-oligomerization and the binding between ASK1 and TRAF2. CIIA also repressed the OGD/R-induced activation of caspase-3 in neuronal cells. Taken together, our results suggest that CIIA attenuates neurotoxicity caused by OGD/R through inhibiting ASK1-dependent signaling events. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | ISCHEMIC BRAIN-INJURY | - |
dc.subject | STRESS-RESPONSE | - |
dc.subject | ASK1 | - |
dc.subject | ACTIVATION | - |
dc.subject | PATHWAY | - |
dc.subject | KINASE | - |
dc.subject | TRANSLOCATION | - |
dc.subject | ATTENUATION | - |
dc.subject | PROTEIN | - |
dc.title | CIIA negatively regulates neuronal cell death induced by oxygen-glucose deprivation and reoxygenation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Eui-Ju | - |
dc.identifier.doi | 10.1007/s11010-014-2181-5 | - |
dc.identifier.scopusid | 2-s2.0-84912038108 | - |
dc.identifier.wosid | 000344394700016 | - |
dc.identifier.bibliographicCitation | MOLECULAR AND CELLULAR BIOCHEMISTRY, v.397, no.1-2, pp.139 - 146 | - |
dc.relation.isPartOf | MOLECULAR AND CELLULAR BIOCHEMISTRY | - |
dc.citation.title | MOLECULAR AND CELLULAR BIOCHEMISTRY | - |
dc.citation.volume | 397 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 139 | - |
dc.citation.endPage | 146 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | ISCHEMIC BRAIN-INJURY | - |
dc.subject.keywordPlus | STRESS-RESPONSE | - |
dc.subject.keywordPlus | ASK1 | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordPlus | TRANSLOCATION | - |
dc.subject.keywordPlus | ATTENUATION | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordAuthor | ASK1 | - |
dc.subject.keywordAuthor | CIIA | - |
dc.subject.keywordAuthor | Oxygen and glucose deprivation | - |
dc.subject.keywordAuthor | Reoxygenation | - |
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