Dexmedetomidine Preconditioning Attenuates Cisplatin-Induced Ototoxicity in Zebrafish
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Min, Too Jae | - |
dc.contributor.author | Kim, Woon Young | - |
dc.contributor.author | Ha, Young Ran | - |
dc.contributor.author | Jeong, In Young | - |
dc.contributor.author | Yoo, Ji Young | - |
dc.date.accessioned | 2021-09-05T02:36:37Z | - |
dc.date.available | 2021-09-05T02:36:37Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-12 | - |
dc.identifier.issn | 1976-8710 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/96673 | - |
dc.description.abstract | Objectives. Utilisation of high-frequency drills is known to increase noise induced hearing loss due to increasing the damages of inner ear cells. This study aimed to investigate whether preconditioning by using dexmedetomidine (DEX) decreased the occurrence of ischemia in inner cells of the ear. Methods. We utilised a transgenic zebrafish line Brn3C, and the embryos were collected from breeding adult zebrafish. Five-day-old larvae were cultured at the density of 50 embryos, and the larvae were classified into 4 groups: control, cisplatin group, DEX group, and DEX+yohimbine; adrenoreceptor blocker group. The DEX group was categorised into 3 subgroups by dosage; 0.1, 1, and 10 mu M. Preconditioning was performed for 150 minutes and then exposed to cisplatin for 6 hours. The experiment was performed in 7 replicates for each group and the number of hair cells in 3 parts of the neuromasts of each fish was determined. Results. Hair cell apoptosis by cisplatin was attenuated more significantly in the DEX preconditioning group than in the control group. However, the preconditioning effects were not blocked by yohimbine. Conclusion. The results of this study suggest that hearing loss caused by vibration-induced noise could be reduced by using DEX and may occur through other mechanisms rather than adreno-receptors. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC OTORHINOLARYNGOL | - |
dc.subject | SENSORINEURAL HEARING | - |
dc.subject | VOLATILE ANESTHETICS | - |
dc.subject | IN-VITRO | - |
dc.subject | REPERFUSION | - |
dc.subject | ISCHEMIA | - |
dc.subject | EXPRESSION | - |
dc.subject | RECEPTORS | - |
dc.subject | HYPOXIA | - |
dc.subject | IMPACT | - |
dc.subject | INJURY | - |
dc.title | Dexmedetomidine Preconditioning Attenuates Cisplatin-Induced Ototoxicity in Zebrafish | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Min, Too Jae | - |
dc.contributor.affiliatedAuthor | Kim, Woon Young | - |
dc.identifier.doi | 10.3342/ceo.2014.7.4.275 | - |
dc.identifier.scopusid | 2-s2.0-84911445624 | - |
dc.identifier.wosid | 000346221200007 | - |
dc.identifier.bibliographicCitation | CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY, v.7, no.4, pp.275 - 280 | - |
dc.relation.isPartOf | CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY | - |
dc.citation.title | CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY | - |
dc.citation.volume | 7 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 275 | - |
dc.citation.endPage | 280 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001936552 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Otorhinolaryngology | - |
dc.relation.journalWebOfScienceCategory | Otorhinolaryngology | - |
dc.subject.keywordPlus | SENSORINEURAL HEARING | - |
dc.subject.keywordPlus | VOLATILE ANESTHETICS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | REPERFUSION | - |
dc.subject.keywordPlus | ISCHEMIA | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | RECEPTORS | - |
dc.subject.keywordPlus | HYPOXIA | - |
dc.subject.keywordPlus | IMPACT | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordAuthor | Preconditioning | - |
dc.subject.keywordAuthor | Dexmedetomidine | - |
dc.subject.keywordAuthor | Hearing loss | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.