ERDR1 enhances human NK cell cytotoxicity through an actin-regulated degranulation-dependent pathway
DC Field | Value | Language |
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dc.contributor.author | Lee, Ha-Reum | - |
dc.contributor.author | Huh, Scarlett Yoona | - |
dc.contributor.author | Hur, Dae Young | - |
dc.contributor.author | Jeong, Hyuk | - |
dc.contributor.author | Kim, Tae Sung | - |
dc.contributor.author | Kim, Sang Yoon | - |
dc.contributor.author | Park, Seung Beom | - |
dc.contributor.author | Yang, Yoolhee | - |
dc.contributor.author | Bang, Sa Ik | - |
dc.contributor.author | Park, Hyunjeong | - |
dc.contributor.author | Cho, Daeho | - |
dc.date.accessioned | 2021-09-05T03:23:53Z | - |
dc.date.available | 2021-09-05T03:23:53Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-11 | - |
dc.identifier.issn | 0008-8749 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/96888 | - |
dc.description.abstract | Erythroid differentiation regulator 1 (ERDR1), which is a stress-related survival factor, exhibits anticancer effects against melanoma. However, the function of ERDR1 on immune cells has not been examined. We investigated whether ERDR1 regulates the cytotoxic ability of human natural killer (NK) cells, which are known as innate effector lymphocytes. In this study, treatment with recombinant ERDR1 resulted in enhanced NK cell cytotoxicity through the secretion of lytic granules. Furthermore, actin modulation was involved in the ERDR1-enhanced NK cell cytotoxicity. ERDR1 stimulated actin accumulation at the immunological synapse, which was induced by the activation of Vav-1 in NK cells. These findings suggest new insight into the function of ERDR1 function in the human immune system. (C) 2014 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | NATURAL-KILLER-CELLS | - |
dc.subject | EXCHANGE FACTOR VAV | - |
dc.subject | SIGNALING PATHWAYS | - |
dc.subject | T-CELLS | - |
dc.subject | MEDIATED CYTOTOXICITY | - |
dc.subject | DEFICIENT MICE | - |
dc.subject | FAS LIGAND | - |
dc.subject | ACTIVATION | - |
dc.subject | RECEPTOR | - |
dc.subject | PERFORIN | - |
dc.title | ERDR1 enhances human NK cell cytotoxicity through an actin-regulated degranulation-dependent pathway | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Tae Sung | - |
dc.identifier.doi | 10.1016/j.cellimm.2014.10.002 | - |
dc.identifier.scopusid | 2-s2.0-84910037842 | - |
dc.identifier.wosid | 000345530600013 | - |
dc.identifier.bibliographicCitation | CELLULAR IMMUNOLOGY, v.292, no.1-2, pp.78 - 84 | - |
dc.relation.isPartOf | CELLULAR IMMUNOLOGY | - |
dc.citation.title | CELLULAR IMMUNOLOGY | - |
dc.citation.volume | 292 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 78 | - |
dc.citation.endPage | 84 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | NATURAL-KILLER-CELLS | - |
dc.subject.keywordPlus | EXCHANGE FACTOR VAV | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | MEDIATED CYTOTOXICITY | - |
dc.subject.keywordPlus | DEFICIENT MICE | - |
dc.subject.keywordPlus | FAS LIGAND | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | PERFORIN | - |
dc.subject.keywordAuthor | Natural killer cell | - |
dc.subject.keywordAuthor | Erythroid differentiation regulator 1 | - |
dc.subject.keywordAuthor | Cytotoxicity | - |
dc.subject.keywordAuthor | Immune system | - |
dc.subject.keywordAuthor | Actin | - |
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