Chemokine receptor 5 Delta 32 polymorphism and systemic lupus erythematosus, vasculitis, and primary Sjogren's syndrome Meta-analysis of possible associations
DC Field | Value | Language |
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dc.contributor.author | Lee, Y. H. | - |
dc.contributor.author | Kim, J. -H. | - |
dc.contributor.author | Song, G. G. | - |
dc.date.accessioned | 2021-09-05T03:34:51Z | - |
dc.date.available | 2021-09-05T03:34:51Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-11 | - |
dc.identifier.issn | 0340-1855 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/96971 | - |
dc.description.abstract | Objective. The aim of this study was to determine whether the functional chemokine receptor 5 delta32 (CCR5-Delta 32) polymorphism is associated with susceptibility to systemic lupus erythematosus (SLE), vasculitis, and primary Sjogren's syndrome (pSS). Results. A total of 12 studies were analyzed, including 5 on SLE, 5 on vasculitis, and 2 on pSS, encompassing 1881 patients and 2391 controls. Meta-analysis indicated no association between SLE and the CCR5-Delta 32 allele (OR 0.842, 95% CI 0.793-1.804, p= 0.657), and no association between the CCR5-Delta 32 allele and SLE in Europeans (OR 0.647, 95% CI 0.306-1.368, p= 0.255). Meta-analysis of the CCR5-Delta 32 allele and the Delta 32 Delta 32+Delta 32 W genotype showed no association with lupus nephritis (LN; OR 1.771, 95% CI 0.4756.595, p= 0.395; OR 2.192, 95% CI 0.18226.42, p= 0.537, respectively). In addition, meta- analysis revealed no association between the CCR5-Delta 32 allele and vasculitis in all study subjects and in Europeans (OR 1.241, 95% CI 0.951-1.620, p= 0.111; OR 1.359, 95% CI 0.803-2.303, p= 0.254, respectively). However, the overall OR for the CCR5-Delta 32 allele was significantly higher in Kawasaki disease (KD; OR 1.746, 95% CI 1.003-2.955, p= 0.038) and the meta-analysis of the Delta 32 Delta 32+Delta 32 W genotype showed a trend indicating an association with KD (OR 1.683, 95% CI 0.9213.077, p= 0.091). No association was found between the CCR5-Delta 32 polymorphism and pSS. Conclusion. This meta-analysis demonstrates that the CCR5-Delta 32 polymorphism is associated with KD, but does not facilitate susceptibility to SLE, LN, or pSS. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER HEIDELBERG | - |
dc.subject | RHEUMATOID-ARTHRITIS | - |
dc.subject | KAWASAKI-DISEASE | - |
dc.subject | BEHCETS-DISEASE | - |
dc.subject | GENE POLYMORPHISMS | - |
dc.subject | ITALIAN PATIENTS | - |
dc.subject | HIV-1 INFECTION | - |
dc.subject | CCR5 | - |
dc.subject | SUSCEPTIBILITY | - |
dc.subject | CCR5-DELTA-32 | - |
dc.subject | POPULATION | - |
dc.title | Chemokine receptor 5 Delta 32 polymorphism and systemic lupus erythematosus, vasculitis, and primary Sjogren's syndrome Meta-analysis of possible associations | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Y. H. | - |
dc.contributor.affiliatedAuthor | Song, G. G. | - |
dc.identifier.doi | 10.1007/s00393-014-1356-5 | - |
dc.identifier.scopusid | 2-s2.0-84894677023 | - |
dc.identifier.wosid | 000344872300014 | - |
dc.identifier.bibliographicCitation | ZEITSCHRIFT FUR RHEUMATOLOGIE, v.73, no.9, pp.848 - 855 | - |
dc.relation.isPartOf | ZEITSCHRIFT FUR RHEUMATOLOGIE | - |
dc.citation.title | ZEITSCHRIFT FUR RHEUMATOLOGIE | - |
dc.citation.volume | 73 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 848 | - |
dc.citation.endPage | 855 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | KAWASAKI-DISEASE | - |
dc.subject.keywordPlus | BEHCETS-DISEASE | - |
dc.subject.keywordPlus | GENE POLYMORPHISMS | - |
dc.subject.keywordPlus | ITALIAN PATIENTS | - |
dc.subject.keywordPlus | HIV-1 INFECTION | - |
dc.subject.keywordPlus | CCR5 | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
dc.subject.keywordPlus | CCR5-DELTA-32 | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordAuthor | Autoimmune diseases | - |
dc.subject.keywordAuthor | Mucocutaneous lymph node syndrome | - |
dc.subject.keywordAuthor | Disease susceptibility | - |
dc.subject.keywordAuthor | Genetic polymorphisms | - |
dc.subject.keywordAuthor | Publication bias | - |
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