A Functional Polymorphism in CSF1R Gene Is a Novel Susceptibility Marker for Lung Cancer among Never-Smoking Females
DC Field | Value | Language |
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dc.contributor.author | Kang, Hyo-Gyoung | - |
dc.contributor.author | Lee, Shin Yup | - |
dc.contributor.author | Jeon, Hyo-Sung | - |
dc.contributor.author | Choi, Yi Young | - |
dc.contributor.author | Kim, Soyoun | - |
dc.contributor.author | Lee, Won Kee | - |
dc.contributor.author | Lee, Hyun Chul | - |
dc.contributor.author | Choi, Jin Eun | - |
dc.contributor.author | Bae, Eun Young | - |
dc.contributor.author | Yoo, Seung Soo | - |
dc.contributor.author | Lee, Jaehee | - |
dc.contributor.author | Cha, Seung Ick | - |
dc.contributor.author | Kim, Chang Ho | - |
dc.contributor.author | Lee, Myung Hoon | - |
dc.contributor.author | Kim, Young Tae | - |
dc.contributor.author | Kim, Jin Hee | - |
dc.contributor.author | Hong, Yun-Chul | - |
dc.contributor.author | Kim, Yeul Hong | - |
dc.contributor.author | Park, Jae Yong | - |
dc.date.accessioned | 2021-09-05T03:46:24Z | - |
dc.date.available | 2021-09-05T03:46:24Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-11 | - |
dc.identifier.issn | 1556-0864 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/97022 | - |
dc.description.abstract | Introduction: It has been estimated that the proportion of never-smokers among females with lung cancer is 53% worldwide and 75% in Korea. We conducted a two-stage study to identify genetic factors responsible for lung cancer susceptibility in female never-smokers. Materials and Methods: In a discovery set, 1969 potentially functional single nucleotide polymorphisms (SNPs) of 1151 genes, which were related to cancer development and progression, were evaluated using the Affymetrix custom-made GeneChip in 181 female never-smokers with lung cancer and 179 controls. A replication study was performed on an independent cohort of 596 cases and 1194 healthy controls. Results: Sixteen SNPs with p < 0.05 for genotype distribution in the discovery set were enrolled in the replication study. Among 16 SNPs, three SNPs (colony-stimulating factor 1 receptor [CSF1R] rs10079250A>G, tumor protein p63 [TP63] rs7631358G>A, and corepressor interacting with RBPJ 1 [CIR1] rs13009079T>C) were found to be significantly associated with lung cancer in the same direction as the discovery set. Homology-based model for CSF1R indicated that the rs10079250A>G leads to increased positive charge of CSF-binding region of CSF1R, thereby increasing the chance of binding between CSF and CSF1R. In addition, this SNP was found to increase the phosphorylation of a mitogen-activated protein kinase, JNK. Conclusions: Our results suggest that the three SNPs, particularly CSF1R rs10079250, may contribute to lung cancer susceptibility in never-smoking females. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.subject | GENOME-WIDE ASSOCIATION | - |
dc.subject | RISK | - |
dc.subject | RECEPTOR | - |
dc.subject | SMOKERS | - |
dc.subject | LOCUS | - |
dc.subject | ADENOCARCINOMA | - |
dc.subject | EXPRESSION | - |
dc.subject | CSF-1 | - |
dc.subject | TP63 | - |
dc.subject | METASTASIS | - |
dc.title | A Functional Polymorphism in CSF1R Gene Is a Novel Susceptibility Marker for Lung Cancer among Never-Smoking Females | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yeul Hong | - |
dc.identifier.doi | 10.1097/JTO.0000000000000310 | - |
dc.identifier.scopusid | 2-s2.0-84925750728 | - |
dc.identifier.wosid | 000344368100013 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THORACIC ONCOLOGY, v.9, no.11, pp.1647 - 1655 | - |
dc.relation.isPartOf | JOURNAL OF THORACIC ONCOLOGY | - |
dc.citation.title | JOURNAL OF THORACIC ONCOLOGY | - |
dc.citation.volume | 9 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1647 | - |
dc.citation.endPage | 1655 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.subject.keywordPlus | GENOME-WIDE ASSOCIATION | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | SMOKERS | - |
dc.subject.keywordPlus | LOCUS | - |
dc.subject.keywordPlus | ADENOCARCINOMA | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CSF-1 | - |
dc.subject.keywordPlus | TP63 | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.subject.keywordAuthor | Lung cancer | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | Never-smokers | - |
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