The incidence and risk factors of acute kidney injury after hepatobiliary surgery: a prospective observational study
DC Field | Value | Language |
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dc.contributor.author | Cho, Eunjung | - |
dc.contributor.author | Kim, Sun-Chul | - |
dc.contributor.author | Kim, Myung-Gyu | - |
dc.contributor.author | Jo, Sang-Kyung | - |
dc.contributor.author | Cho, Won-Yong | - |
dc.contributor.author | Kim, Hyoung-Kyu | - |
dc.date.accessioned | 2021-09-05T03:54:23Z | - |
dc.date.available | 2021-09-05T03:54:23Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-10-23 | - |
dc.identifier.issn | 1471-2369 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/97057 | - |
dc.description.abstract | Background: Although intraperitoneal surgery is a major operation associated with postoperative acute kidney injury (AKI), the incidence, risk factors, and long-term renal outcome are not well known. We aimed to determine the risk factors and 6 months renal outcome in patients with clinical or subclinical AKI after hepatobiliary surgery. We also assessed the validity of urine neutrophil gelatinase-associated lipocalin (NGAL) in the early detection of AKI or prediction of renal outcome. Methods: This prospective observational study enrolled patients with normal renal function who underwent hepatobiliary surgeries. Urine and serum samples were collected for NGAL measurement. Results: Among 131 patients, 10 (7.6%) developed postoperative AKI. Urine NGAL at 12 h postsurgery was the most predictive parameter for the diagnosis of AKI (cutoff, 92.85 ng/mL). With the cutoff value, subclinical AKI was diagnosed in 42 (32.1%) patients. Patients with clinical AKI and those with subclinical AKI were assigned to the AKI group. The AKI group had significantly higher model for end-stage liver disease and sodium (MELD-Na) score, lower albumin level, and longer hospital stay after surgery than the non-AKI group. Older age and higher MELD-Na score were independent risk factors for the development of postoperative AKI. At 6 months postsurgery, the estimated glomerular filtration rate (eGFR) in the AKI group was significantly lower than that in the non-AKI group, although the baseline eGFR was not different. In multiple linear regression analysis, the maximum urine NGAL level during 24 h postsurgery, intraoperative fluid balance, and having liver transplantation were significantly associated with a poor 6 months renal outcome. Conclusion: Urine NGAL was useful in the early diagnosis of postoperative AKI as well as in predicting the 6 months renal outcome after hepatobiliary surgery. A considerable proportion of patients developed subclinical AKI, and these patients showed worse renal outcome compared with the non-AKI group. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | BMC | - |
dc.subject | GELATINASE-ASSOCIATED LIPOCALIN | - |
dc.subject | CARDIAC-SURGERY | - |
dc.subject | HEPATOCELLULAR-CARCINOMA | - |
dc.subject | SUBCLINICAL AKI | - |
dc.subject | EARLY BIOMARKER | - |
dc.subject | PREDICTOR | - |
dc.subject | RECOVERY | - |
dc.subject | OUTCOMES | - |
dc.subject | SODIUM | - |
dc.subject | NGAL | - |
dc.title | The incidence and risk factors of acute kidney injury after hepatobiliary surgery: a prospective observational study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Myung-Gyu | - |
dc.contributor.affiliatedAuthor | Jo, Sang-Kyung | - |
dc.contributor.affiliatedAuthor | Cho, Won-Yong | - |
dc.contributor.affiliatedAuthor | Kim, Hyoung-Kyu | - |
dc.identifier.doi | 10.1186/1471-2369-15-169 | - |
dc.identifier.scopusid | 2-s2.0-84923935389 | - |
dc.identifier.wosid | 000344965000001 | - |
dc.identifier.bibliographicCitation | BMC NEPHROLOGY, v.15 | - |
dc.relation.isPartOf | BMC NEPHROLOGY | - |
dc.citation.title | BMC NEPHROLOGY | - |
dc.citation.volume | 15 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.subject.keywordPlus | GELATINASE-ASSOCIATED LIPOCALIN | - |
dc.subject.keywordPlus | CARDIAC-SURGERY | - |
dc.subject.keywordPlus | HEPATOCELLULAR-CARCINOMA | - |
dc.subject.keywordPlus | SUBCLINICAL AKI | - |
dc.subject.keywordPlus | EARLY BIOMARKER | - |
dc.subject.keywordPlus | PREDICTOR | - |
dc.subject.keywordPlus | RECOVERY | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordPlus | SODIUM | - |
dc.subject.keywordPlus | NGAL | - |
dc.subject.keywordAuthor | Acute kidney injury | - |
dc.subject.keywordAuthor | Postoperative complications | - |
dc.subject.keywordAuthor | Neutrophil gelatinase-associated lipocalin | - |
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