Simple Fabrication Method for a Porous Poly(vinyl alcohol) Matrix by Multisolvent Mixtures for an Air-Exposed Model of the Lung Epithelial System
DC Field | Value | Language |
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dc.contributor.author | Chae, Su-Kyoung | - |
dc.contributor.author | Mun, Cho Hay | - |
dc.contributor.author | Noh, Da-Yoon | - |
dc.contributor.author | Kong, Edward | - |
dc.contributor.author | Lee, Sang-Hoon | - |
dc.date.accessioned | 2021-09-05T03:57:51Z | - |
dc.date.available | 2021-09-05T03:57:51Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-10-21 | - |
dc.identifier.issn | 0743-7463 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/97073 | - |
dc.description.abstract | We introduce a simple and easy method for fabricating a thin and porous matrix that can be used as an extracellular matrix (ECM). A porous poly(vinyl alcohol) (PVA) matrix was created through recrystallization by multiple solvents under distilled water (DW), isopropyl alcohol (IPA), and a combination of DW and IPA. The crysatllization was driven by precipitating and dissolving a solute in a solution of a solvent and a nonsolvent, which induced the formation of microspheres in the IPA. The crystal structure depended on the ratio of the solvent/nonsolvent and the concentration of the PVA aqueous solution; these properties were used to tune the thickness, size, and porosity of the matrices. The resulting PVA matrix was chemically stabilized through a reaction with glutaraldehyde in the IPA solution. We demonstrated that a very thin and porous PVA matrix provided an effective functional model of the lung epithelial system. Lung epithelial cells (A549) displayed a high affinity for this matrix, which was permeable to the culture medium. These properties facilitated culturing under the air environment. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | OSTEOGENIC DIFFERENTIATION | - |
dc.subject | STEM-CELLS | - |
dc.subject | IN-VITRO | - |
dc.subject | SCAFFOLDS | - |
dc.subject | POROSITY | - |
dc.subject | PROLIFERATION | - |
dc.subject | HYDROGELS | - |
dc.subject | MEMBRANE | - |
dc.subject | FIBERS | - |
dc.subject | SCALE | - |
dc.title | Simple Fabrication Method for a Porous Poly(vinyl alcohol) Matrix by Multisolvent Mixtures for an Air-Exposed Model of the Lung Epithelial System | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Sang-Hoon | - |
dc.identifier.doi | 10.1021/la501453h | - |
dc.identifier.scopusid | 2-s2.0-84908072322 | - |
dc.identifier.wosid | 000343638800001 | - |
dc.identifier.bibliographicCitation | LANGMUIR, v.30, no.41, pp.12107 - 12113 | - |
dc.relation.isPartOf | LANGMUIR | - |
dc.citation.title | LANGMUIR | - |
dc.citation.volume | 30 | - |
dc.citation.number | 41 | - |
dc.citation.startPage | 12107 | - |
dc.citation.endPage | 12113 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.subject.keywordPlus | OSTEOGENIC DIFFERENTIATION | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | SCAFFOLDS | - |
dc.subject.keywordPlus | POROSITY | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | HYDROGELS | - |
dc.subject.keywordPlus | MEMBRANE | - |
dc.subject.keywordPlus | FIBERS | - |
dc.subject.keywordPlus | SCALE | - |
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