Shedding of epithin/PRSS14 is induced by TGF-beta and mediated by tumor necrosis factor-alpha converting enzyme
DC Field | Value | Language |
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dc.contributor.author | Lee, Hyo Seon | - |
dc.contributor.author | Park, Bo Mi | - |
dc.contributor.author | Cho, Youngkyung | - |
dc.contributor.author | Kim, Sauryang | - |
dc.contributor.author | Kim, Chungho | - |
dc.contributor.author | Kim, Moon Gyo | - |
dc.contributor.author | Park, Dongeun | - |
dc.date.accessioned | 2021-09-05T04:17:02Z | - |
dc.date.available | 2021-09-05T04:17:02Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-10-03 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/97117 | - |
dc.description.abstract | Epithin/PRSS14, a type II transmembrane serine protease, plays critical roles in cancer metastasis. Previously, we have reported that epithin/PRSS14 undergoes ectodomain shedding in response to phorbol myristate acetate (PMA) stimulation. In this study, we show that transforming growth factor-beta (TGF-beta) induces rapid epithin/PRSS14 shedding through receptor mediated pathway in 427.1.86 thymoma cells. Tumor necrosis factor-a converting enzyme (TACE) is responsible for this shedding. Amino acid sequence encompassing the putative shedding cleavage site of epithin/PRSS14 exhibit strong homology to the cleavage site of L-selectin, a known TACE substrate. TACE inhibitor, TAPI-0 and TACE siRNA greatly reduced TGF-beta-induced epithin/PRSS14 shedding. TGF-beta treatment induces translocation of intracellular pool of TACE to the membrane where epithin/PRSS14 resides. These findings suggest that TGF-beta induces epithin/PRSS14 shedding by mediating translocation of epithin/PRSS14 sheddase, TACE, to the membrane. (C) 2014 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | SERINE-PROTEASE | - |
dc.subject | CANCER-CELLS | - |
dc.subject | ECTODOMAIN CLEAVAGE | - |
dc.subject | GROWTH-FACTORS | - |
dc.subject | BREAST-CANCER | - |
dc.subject | MATRIPTASE | - |
dc.subject | ADHESION | - |
dc.subject | INFLAMMATION | - |
dc.subject | PROTEOLYSIS | - |
dc.subject | ACTIVATION | - |
dc.title | Shedding of epithin/PRSS14 is induced by TGF-beta and mediated by tumor necrosis factor-alpha converting enzyme | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Chungho | - |
dc.identifier.doi | 10.1016/j.bbrc.2014.09.055 | - |
dc.identifier.scopusid | 2-s2.0-84907898299 | - |
dc.identifier.wosid | 000343350900035 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.452, no.4, pp.1084 - 1090 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 452 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1084 | - |
dc.citation.endPage | 1090 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | SERINE-PROTEASE | - |
dc.subject.keywordPlus | CANCER-CELLS | - |
dc.subject.keywordPlus | ECTODOMAIN CLEAVAGE | - |
dc.subject.keywordPlus | GROWTH-FACTORS | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | MATRIPTASE | - |
dc.subject.keywordPlus | ADHESION | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | PROTEOLYSIS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordAuthor | Epithin | - |
dc.subject.keywordAuthor | Ectodomain shedding | - |
dc.subject.keywordAuthor | TGF-beta | - |
dc.subject.keywordAuthor | Tumor necrosis factor-alpha converting enzyme (TACE) | - |
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