There is no association between the serotonin receptor gene and bipolar I disorder in the Korean population
DC Field | Value | Language |
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dc.contributor.author | Kim, Yong-Ku | - |
dc.contributor.author | Hwang, Jung-A | - |
dc.contributor.author | Lee, Heon-Jeong | - |
dc.contributor.author | Lee, Bun-Hee | - |
dc.contributor.author | Na, Kyoung-Sae | - |
dc.date.accessioned | 2021-09-05T04:28:08Z | - |
dc.date.available | 2021-09-05T04:28:08Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-10 | - |
dc.identifier.issn | 0803-9488 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/97189 | - |
dc.description.abstract | Objective: Despite the close relationship between the functional polymorphism C(-1019) G (rs6295) of the serotonergic 1A receptor (5-HT1A) and mood, few studies have investigated the relationship between rs6295 and bipolar disorder. Aims: In this study, we aimed to investigate whether rs6295 is associated with clinical prognosis and treatment response in patients with bipolar I disorder acute manic episodes. Methods : One hundred twenty-eight patients with bipolar I disorder and one hundred sixty-eight healthy controls were recruited. Associations between patients with bipolar I disorder and healthy controls were compared. In addition, age at onset, number of admissions, and treatment response, including response rate, mean changes in manic symptoms, number of anti-manic agents and the total dosage of mood stabilizers for acute manic symptoms were compared between the rs6295 GG and CG + CC groups in patients with bipolar I disorder. We conducted a separate subgroup analysis according to gender. Results : There were no differences in frequency between patients and controls. In patients with bipolar disorder, clinical prognosis and treatment response were no different between GG and CG + CC groups. However, in a subgroup analysis according to gender, male, but not female, patients in the GG group had a longer duration of illness and a greater number of both previous episodes and psychiatric ward admissions than did the GC + CC group. Conclusions : Further studies should investigate the relationship between 5-HT1A polymorphisms and bipolar disorder in terms of mood episode and gender. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.subject | TREATMENT RESPONSE | - |
dc.subject | MAJOR DEPRESSION | - |
dc.subject | 5-HT1A | - |
dc.subject | POLYMORPHISM | - |
dc.subject | C(-1019)G | - |
dc.subject | HTR1A | - |
dc.subject | ANTIPSYCHOTICS | - |
dc.subject | AGGRESSION | - |
dc.subject | REPRESSION | - |
dc.subject | MANAGEMENT | - |
dc.title | There is no association between the serotonin receptor gene and bipolar I disorder in the Korean population | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yong-Ku | - |
dc.contributor.affiliatedAuthor | Lee, Heon-Jeong | - |
dc.identifier.doi | 10.3109/08039488.2013.877071 | - |
dc.identifier.scopusid | 2-s2.0-84907180138 | - |
dc.identifier.wosid | 000342207100008 | - |
dc.identifier.bibliographicCitation | NORDIC JOURNAL OF PSYCHIATRY, v.68, no.7, pp.488 - 493 | - |
dc.relation.isPartOf | NORDIC JOURNAL OF PSYCHIATRY | - |
dc.citation.title | NORDIC JOURNAL OF PSYCHIATRY | - |
dc.citation.volume | 68 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 488 | - |
dc.citation.endPage | 493 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | ssci | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.subject.keywordPlus | TREATMENT RESPONSE | - |
dc.subject.keywordPlus | MAJOR DEPRESSION | - |
dc.subject.keywordPlus | 5-HT1A | - |
dc.subject.keywordPlus | POLYMORPHISM | - |
dc.subject.keywordPlus | C(-1019)G | - |
dc.subject.keywordPlus | HTR1A | - |
dc.subject.keywordPlus | ANTIPSYCHOTICS | - |
dc.subject.keywordPlus | AGGRESSION | - |
dc.subject.keywordPlus | REPRESSION | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordAuthor | Bipolar disorder | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | Mood stabilizer | - |
dc.subject.keywordAuthor | Serotonin 1A receptor | - |
dc.subject.keywordAuthor | Treatment | - |
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