Trans-anethole protects cortical neuronal cells against oxygen-glucose deprivation/reoxygenation
- Authors
- Ryu, Sangwoo; Seol, Geun Hee; Park, Hyeon; Choi, In-Young
- Issue Date
- 10월-2014
- Publisher
- SPRINGER-VERLAG ITALIA SRL
- Keywords
- Trans-anethole; Oxygen-glucose deprivation/reoxygenation; Neuroprotection; Excitotoxicity; Oxidative stress
- Citation
- NEUROLOGICAL SCIENCES, v.35, no.10, pp.1541 - 1547
- Indexed
- SCIE
SCOPUS
- Journal Title
- NEUROLOGICAL SCIENCES
- Volume
- 35
- Number
- 10
- Start Page
- 1541
- End Page
- 1547
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/97200
- DOI
- 10.1007/s10072-014-1791-8
- ISSN
- 1590-1874
- Abstract
- Trans-anethole has been studied on pharmacological properties such as anti-inflammation, anti-oxidative stress, antifungal and anticancer. However, to date, the anti-ischemic effects of trans-anethole have not been assessed. Therefore, we investigated the neuroprotection of trans-anethole against oxygen-glucose deprivation/reoxygenation (OGD/R)-induced cortical neuronal cell injury, an in vitro model of ischemia. The abilities of trans-anethole to block excitotoxicity, oxidative stress and mitochondrial dysfunction were evaluated in OGD/R-induced neurons. Trans-anethole significantly ameliorated OGD/R-induced neuronal cell injury by attenuating the intracellular calcium overload via the activation of NMDA receptors. Trans-anethole also inhibited OGD/R-induced reactive oxygen species overproduction, which may be derived from the scavenging activity in peroxyl radicals, assessed in an oxygen radical absorbance capacity assay. Furthermore, trans-anethole was shown to attenuate the depolarization of mitochondrial transmembrane. These results indicated that the neuroprotective effect of trans-anethole on OGD/R-induced neuronal injury might be due to its ability to inhibit excitotoxicity, oxidative stress and mitochondrial dysfunction. Considering these multiple pathways causing ischemic neuronal damage, the multi-functional effect of trans-anethole suggested that it may be effective in treating ischemic stroke.
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