Transcriptional and posttranslational regulation of insulin-like growth factor binding protein-3 by Akt3
DC Field | Value | Language |
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dc.contributor.author | Jin, Quanri | - |
dc.contributor.author | Lee, Hyo-Jong | - |
dc.contributor.author | Min, Hye-Young | - |
dc.contributor.author | Smith, John Kendal | - |
dc.contributor.author | Hwang, Su Jung | - |
dc.contributor.author | Whang, Young Mi | - |
dc.contributor.author | Kim, Woo-Young | - |
dc.contributor.author | Kim, Yeul Hong | - |
dc.contributor.author | Lee, Ho-Young | - |
dc.date.accessioned | 2021-09-05T04:36:11Z | - |
dc.date.available | 2021-09-05T04:36:11Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-10 | - |
dc.identifier.issn | 0143-3334 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/97236 | - |
dc.description.abstract | Insulin-like growth factor (IGF)-dependent and -independent antitumor activities of insulin-like growth factor binding protein-3 (IGFBP-3) have been proposed in human non-small cell lung cancer (NSCLC) cells. However, the mechanism underlying regulation of IGFBP-3 expression in NSCLC cells is not well understood. In this study, we show that activation of Akt, especially Akt3, plays a major role in the mRNA expression and protein stability of IGFBP-3 and thus antitumor activities of IGFBP-3 in NSCLC cells. When Akt was activated by genomic or pharmacologic approaches, IGFBP-3 transcription and protein stability were decreased. Conversely, suppression of Akt increased IGFBP-3 mRNA levels and protein stability in NSCLC cell lines. Characterization of the effects of constitutively active form of each Akt subtype (HA-Akt-DD) on IGFBP-3 expression in NSCLC cells and a xenograft model indicated that Akt3 plays a major role in the Akt-mediated regulation of IGFBP-3 expression and thus suppression of Akt effectively enhances the antitumor activities of IGFBP-3 in NSCLC cells with Akt3 overactivation. Collectively, these data suggest a novel function of Akt3 as a negative regulator of IGFBP-3, indicating the possible benefit of a combined inhibition of IGFBP-3 and Akt3 for the treatment of patients with NSCLC. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.subject | CELL LUNG-CANCER | - |
dc.subject | NUCLEAR TRANSLOCATION | - |
dc.subject | BREAST-CANCER | - |
dc.subject | DEPENDENT PHOSPHORYLATION | - |
dc.subject | DNA METHYLATION | - |
dc.subject | KINASE-B | - |
dc.subject | PATHWAY | - |
dc.subject | IGFBP-3 | - |
dc.subject | RESISTANCE | - |
dc.subject | EXPRESSION | - |
dc.title | Transcriptional and posttranslational regulation of insulin-like growth factor binding protein-3 by Akt3 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yeul Hong | - |
dc.identifier.doi | 10.1093/carcin/bgu129 | - |
dc.identifier.scopusid | 2-s2.0-84925235981 | - |
dc.identifier.wosid | 000345830400009 | - |
dc.identifier.bibliographicCitation | CARCINOGENESIS, v.35, no.10, pp.2232 - 2243 | - |
dc.relation.isPartOf | CARCINOGENESIS | - |
dc.citation.title | CARCINOGENESIS | - |
dc.citation.volume | 35 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 2232 | - |
dc.citation.endPage | 2243 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | CELL LUNG-CANCER | - |
dc.subject.keywordPlus | NUCLEAR TRANSLOCATION | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | DEPENDENT PHOSPHORYLATION | - |
dc.subject.keywordPlus | DNA METHYLATION | - |
dc.subject.keywordPlus | KINASE-B | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | IGFBP-3 | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | EXPRESSION | - |
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