Enhanced astaxanthin production from microalga, Haematococcus pluvialis by two-stage perfusion culture with stepwise light irradiation
- Authors
- Park, Joon Chul; Choi, Seung Phill; Hong, Min-Eui; Sim, Sang Jun
- Issue Date
- 10월-2014
- Publisher
- SPRINGER
- Keywords
- Microalgae; Haematococcus pluvialis; Astaxanthin; Mixotrophic culture; Perfusion; Stepwise irradiation
- Citation
- BIOPROCESS AND BIOSYSTEMS ENGINEERING, v.37, no.10, pp.2039 - 2047
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOPROCESS AND BIOSYSTEMS ENGINEERING
- Volume
- 37
- Number
- 10
- Start Page
- 2039
- End Page
- 2047
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/97243
- DOI
- 10.1007/s00449-014-1180-y
- ISSN
- 1615-7591
- Abstract
- For efficient astaxanthin production from the culture of green microalga, Haematococcus pluvialis, a two-stage mixotrophic culture system was established with stepwise increased light irradiance. By perfusion process, high density biomass (2.47 g/L) was achieved during the vegetative stage due to no detrimental effect of inhibitory metabolites, which was 3.09 and 1.67 times higher than batch and fed-batch processes, respectively. During the induction stage, biomass and astaxanthin were subsequently produced to the very high level 12.3 g/L and 602 mg/L, under stepwise increased light irradiance (150-450 mu E/m(2)/s), respectively. These results indicate that the combinatorial approach of perfusion culture during the vegetative stage and stepwise light irradiation during the induction stage is a promising strategy for the simultaneous production of high concentration of biomass and astaxanthin in microalgae including H. pluvialis.
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Collections - College of Engineering > Department of Chemical and Biological Engineering > 1. Journal Articles
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