Differential regeneration of myocardial infarction depending on the progression of disease and the composition of biomimetic hydrogel
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yoon, So Jeong | - |
dc.contributor.author | Hong, Soyoung | - |
dc.contributor.author | Fang, Yong Hu | - |
dc.contributor.author | Song, Myeongjin | - |
dc.contributor.author | Son, Kuk Hui | - |
dc.contributor.author | Son, Ho Sung | - |
dc.contributor.author | Kim, Sook Kyoung | - |
dc.contributor.author | Sun, Kyung | - |
dc.contributor.author | Park, Yongdoo | - |
dc.date.accessioned | 2021-09-05T04:43:23Z | - |
dc.date.available | 2021-09-05T04:43:23Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-10 | - |
dc.identifier.issn | 1389-1723 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/97286 | - |
dc.description.abstract | Hydrogel has been used for regenerating myocardial infraction (MI) as a delivery vehicle for cells and growth factors. This study showed that injectable hyaluronic acid (HA)-based hydrogels alone would effectively regenerate the damaged infarcted heart tissue. We found that there are two major factors of regeneration in MI. One is molecular weight of HA and another is the progression of MI; sub-acute and chronic. Rat MI model was prepared by ligating the left anterior descending coronary artery (LAD). Four weeks after injection of hydrogel, functional analysis of the heart and histological analysis was assessed. When different molecular weight HA-based hydrogels with 50 kDa, 130 kDa, and 170 kDa were applied to the infarcted area in the sub-acute model, 50 kDa HA-based hydrogel showed the most significant regeneration of myocardium as well as functional recovery among samples. For the disease progression, 50 kDa HAbased hydrogels were injected to sub-acute and chronic MI models. The regeneration activity was significantly decreased in the chronic models reflecting that injection timing of the therapeutic agents is also major determinants in the regeneration process. These results suggest that injection time and composition of hydrogel are two major points treating MI. (c) 2014, The Society for Biotechnology, Japan. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SOC BIOSCIENCE BIOENGINEERING JAPAN | - |
dc.subject | CROSS-LINKED HYALURONAN | - |
dc.subject | MESENCHYMAL STEM-CELLS | - |
dc.subject | ANGIOGENIC OLIGOSACCHARIDES | - |
dc.subject | ACID | - |
dc.subject | GROWTH | - |
dc.subject | PROMOTES | - |
dc.subject | CHITOSAN | - |
dc.subject | HEART | - |
dc.subject | TRANSPLANTATION | - |
dc.subject | INHIBITION | - |
dc.title | Differential regeneration of myocardial infarction depending on the progression of disease and the composition of biomimetic hydrogel | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Son, Ho Sung | - |
dc.contributor.affiliatedAuthor | Sun, Kyung | - |
dc.contributor.affiliatedAuthor | Park, Yongdoo | - |
dc.identifier.doi | 10.1016/j.jbiosc.2014.04.001 | - |
dc.identifier.scopusid | 2-s2.0-84921635115 | - |
dc.identifier.wosid | 000345189300017 | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOSCIENCE AND BIOENGINEERING, v.118, no.4, pp.461 - 468 | - |
dc.relation.isPartOf | JOURNAL OF BIOSCIENCE AND BIOENGINEERING | - |
dc.citation.title | JOURNAL OF BIOSCIENCE AND BIOENGINEERING | - |
dc.citation.volume | 118 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 461 | - |
dc.citation.endPage | 468 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | CROSS-LINKED HYALURONAN | - |
dc.subject.keywordPlus | MESENCHYMAL STEM-CELLS | - |
dc.subject.keywordPlus | ANGIOGENIC OLIGOSACCHARIDES | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | PROMOTES | - |
dc.subject.keywordPlus | CHITOSAN | - |
dc.subject.keywordPlus | HEART | - |
dc.subject.keywordPlus | TRANSPLANTATION | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordAuthor | Hyaluronic acid | - |
dc.subject.keywordAuthor | Injectable hydrogel | - |
dc.subject.keywordAuthor | Heart function | - |
dc.subject.keywordAuthor | Chronic myocardial infarction | - |
dc.subject.keywordAuthor | Tissue regeneration | - |
dc.subject.keywordAuthor | Molecular weight | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
145 Anam-ro, Seongbuk-gu, Seoul, 02841, Korea+82-2-3290-2963
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.