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A Poly(lactide) Stereocomplex Structure with Modified Magnesium Oxide and Its Effects in Enhancing the Mechanical Properties and Suppressing Inflammation

Authors
Kum, Chang HunCho, YoungjinSeo, Seong HoJoung, Yoon KiAhn, Dong JuneHan, Dong Keun
Issue Date
24-9월-2014
Publisher
WILEY-V C H VERLAG GMBH
Keywords
biomaterials; bioinspired materials; structure-property relationships; polymers; polylactide; stereocomplex; pH neutralization; inflammation
Citation
SMALL, v.10, no.18, pp.3783 - 3794
Indexed
SCIE
SCOPUS
Journal Title
SMALL
Volume
10
Number
18
Start Page
3783
End Page
3794
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/97373
DOI
10.1002/smll.201302880
ISSN
1613-6810
Abstract
Biodegradable polymers such as poly(l-lactide) (PLLA) have been widely utilized as materials for biomedical applications. However, the relatively poor mechanical properties of PLLA and its acid-induced cell inflammation brought about by the acidic byproducts during biodegradation pose severe problems. In this study, these drawbacks of PLLA are addressed using a stereocomplex structure, where oligo-d-lactide-grafted magnesium hydroxide (MgO-ODLA) is synthesized by grafting d-lactide onto the surface of magnesium hydroxide, which is then blended with a PLLA film. The structure, morphology, pH change, thermal and mechanical properties, in-vitro cytotoxicity, and inflammation effect of the MgO-ODLAs and their PLLA composites are evaluated through various analyses. The PLLA/MgO70-ODLA30 (0-20 wt%) composite with a stereocomplex structure shows a 20% increase in its tensile strength and an improvement in the modulus compared to its oligo-l-lactide (PLLA/MgO70-OLLA30) counterpart. The interfacial interaction parameter of PLLA/MgO70-ODLA30 (5.459) has superior properties to those of PLLA/MgO70-OLLA30 (4.013) and PLLA/Mg(OH)(2) (1.774). The cell cytotoxicity and acid-induced inflammatory response are suppressed by the neutralizing effect of the MgO-ODLAs. In addition, the inflammatory problem caused by the rapid acidification of the stereocomplex structure is also addressed. As a result, the stereocomplex structure of the MgO-ODLA/PLLA composite can be used to overcome the problems associated with the biomedical applications of PLLA films.
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