A Poly(lactide) Stereocomplex Structure with Modified Magnesium Oxide and Its Effects in Enhancing the Mechanical Properties and Suppressing Inflammation
- Authors
- Kum, Chang Hun; Cho, Youngjin; Seo, Seong Ho; Joung, Yoon Ki; Ahn, Dong June; Han, Dong Keun
- Issue Date
- 24-9월-2014
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- biomaterials; bioinspired materials; structure-property relationships; polymers; polylactide; stereocomplex; pH neutralization; inflammation
- Citation
- SMALL, v.10, no.18, pp.3783 - 3794
- Indexed
- SCIE
SCOPUS
- Journal Title
- SMALL
- Volume
- 10
- Number
- 18
- Start Page
- 3783
- End Page
- 3794
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/97373
- DOI
- 10.1002/smll.201302880
- ISSN
- 1613-6810
- Abstract
- Biodegradable polymers such as poly(l-lactide) (PLLA) have been widely utilized as materials for biomedical applications. However, the relatively poor mechanical properties of PLLA and its acid-induced cell inflammation brought about by the acidic byproducts during biodegradation pose severe problems. In this study, these drawbacks of PLLA are addressed using a stereocomplex structure, where oligo-d-lactide-grafted magnesium hydroxide (MgO-ODLA) is synthesized by grafting d-lactide onto the surface of magnesium hydroxide, which is then blended with a PLLA film. The structure, morphology, pH change, thermal and mechanical properties, in-vitro cytotoxicity, and inflammation effect of the MgO-ODLAs and their PLLA composites are evaluated through various analyses. The PLLA/MgO70-ODLA30 (0-20 wt%) composite with a stereocomplex structure shows a 20% increase in its tensile strength and an improvement in the modulus compared to its oligo-l-lactide (PLLA/MgO70-OLLA30) counterpart. The interfacial interaction parameter of PLLA/MgO70-ODLA30 (5.459) has superior properties to those of PLLA/MgO70-OLLA30 (4.013) and PLLA/Mg(OH)(2) (1.774). The cell cytotoxicity and acid-induced inflammatory response are suppressed by the neutralizing effect of the MgO-ODLAs. In addition, the inflammatory problem caused by the rapid acidification of the stereocomplex structure is also addressed. As a result, the stereocomplex structure of the MgO-ODLA/PLLA composite can be used to overcome the problems associated with the biomedical applications of PLLA films.
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Collections - College of Engineering > Department of Chemical and Biological Engineering > 1. Journal Articles
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