IL-32 gamma overexpression accelerates streptozotocin (STZ)-induced type 1 diabetes
DC Field | Value | Language |
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dc.contributor.author | Jhun, Hyunjhung | - |
dc.contributor.author | Choi, Jida | - |
dc.contributor.author | Hong, Jaewoo | - |
dc.contributor.author | Lee, Siyoung | - |
dc.contributor.author | Kwak, Areum | - |
dc.contributor.author | Kim, Eunsom | - |
dc.contributor.author | Jo, Seunghyun | - |
dc.contributor.author | Ryoo, Soyoon | - |
dc.contributor.author | Lim, Yoojung | - |
dc.contributor.author | Yoon, Do-Young | - |
dc.contributor.author | Hong, Jin Tae | - |
dc.contributor.author | Kim, Tae Sung | - |
dc.contributor.author | Lee, Youngmin | - |
dc.contributor.author | Song, Keeho | - |
dc.contributor.author | Kim, Soohyun | - |
dc.date.accessioned | 2021-09-05T05:42:51Z | - |
dc.date.available | 2021-09-05T05:42:51Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-09 | - |
dc.identifier.issn | 1043-4666 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/97532 | - |
dc.description.abstract | Interleukin-32 (IL-32) is a cytokine produced by T lymphocytes, natural killer (NK) cells, monocytes and epithelial cells. There are five splicing variants (alpha, beta, gamma, delta, and epsilon) and IL-32 gamma is the most active isoform. We generated human IL-32 gamma transgenic (IL-32 gamma TG) mice, displaying a high level of IL-32 gamma expression in the pancreas. We investigated the effect of IL-32 gamma on streptozotocin (STZ)-induced type I diabetes model using IL-32 gamma TG mice. After a suboptimal diabetogenic dose of STZ administration, IL-32 gamma TG mice showed significantly increased blood glucose level comparing with that of wild type (WT) mice at day 5. Inflammatory cytokines levels such as, IL-6, TNF alpha, IFN gamma and IL-1 beta, in pancreas and liver lysates were accessed by a specific cytokine ELISA. The proinflammatory cytokines were significantly enhanced in the pancreas of IL-32 gamma TG mice comparing to that of WT mice whereas those cytokines levels in liver of IL-32 gamma TG and WT mice were not changed by STZ. These data indicate that the overexpression of IL-32 gamma contributes to initial islet beta-cells injury and inflammation in pancreas and aggravates STZ-induced type 1 diabetes. (C) 2014 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | - |
dc.subject | TRANSGENIC MICE | - |
dc.subject | BETA-CELLS | - |
dc.subject | INTERLEUKIN-32 | - |
dc.subject | CYTOKINE | - |
dc.subject | ISLETS | - |
dc.subject | GENES | - |
dc.subject | DEATH | - |
dc.subject | IL-32 | - |
dc.title | IL-32 gamma overexpression accelerates streptozotocin (STZ)-induced type 1 diabetes | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Tae Sung | - |
dc.identifier.doi | 10.1016/j.cyto.2014.05.002 | - |
dc.identifier.scopusid | 2-s2.0-84901236560 | - |
dc.identifier.wosid | 000340316700002 | - |
dc.identifier.bibliographicCitation | CYTOKINE, v.69, no.1, pp.1 - 5 | - |
dc.relation.isPartOf | CYTOKINE | - |
dc.citation.title | CYTOKINE | - |
dc.citation.volume | 69 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 5 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | TRANSGENIC MICE | - |
dc.subject.keywordPlus | BETA-CELLS | - |
dc.subject.keywordPlus | INTERLEUKIN-32 | - |
dc.subject.keywordPlus | CYTOKINE | - |
dc.subject.keywordPlus | ISLETS | - |
dc.subject.keywordPlus | GENES | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | IL-32 | - |
dc.subject.keywordAuthor | IL-32 gamma transgenic mice | - |
dc.subject.keywordAuthor | Inflammatory cytokine | - |
dc.subject.keywordAuthor | Streptozotocin (STZ)-induced type I diabetes | - |
dc.subject.keywordAuthor | Pancreas | - |
dc.subject.keywordAuthor | Glucose tolerance test | - |
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