Preliminary Study about Sublingual Administration of Bacteria-expressed Pandemic H1N1 Influenza Vaccine in Miniature Pigs
DC Field | Value | Language |
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dc.contributor.author | Kim, Hyekwon | - |
dc.contributor.author | Kim, Jeong-Ki | - |
dc.contributor.author | Song, Hohyun | - |
dc.contributor.author | Choi, Jungah | - |
dc.contributor.author | Shim, Byoungshik | - |
dc.contributor.author | Kang, Bokyu | - |
dc.contributor.author | Moon, Hyoungjoon | - |
dc.contributor.author | Yeom, Minjoo | - |
dc.contributor.author | Kim, Sang-Hyun | - |
dc.contributor.author | Song, Daesub | - |
dc.contributor.author | Song, Manki | - |
dc.date.accessioned | 2021-09-05T05:52:45Z | - |
dc.date.available | 2021-09-05T05:52:45Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-09 | - |
dc.identifier.issn | 1225-8873 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/97602 | - |
dc.description.abstract | Sublingual (SL) administration of influenza vaccine would be non-invasive and effective way to give human populations protective immunity against the virus, especially when pandemic influenza outbreaks. In this study, the efficacy of pandemic influenza virus-based subunit vaccines was tested after sublingual (SL) adjuvant administration in pigs. Eight specific pathogen-free Yucatan pigs were divided into 4 groups: non-vaccinated but challenged (A) and vaccinated and challenged (B, C, and D). The vaccinated groups were subdivided by vaccine type and inoculation route: SL subunit vaccine (hemagglutinin antigen 1 [HA1] + wild-type cholera toxin [wtCT], B); IM subunit vaccine (HA1. + aluminum hydroxide, C); and IM inactivated vaccine (+ aluminum hydroxide, D). The vaccines were administered twice at a 2-week interval. All pigs were challenged with pandemic influenza virus (A/swine/GCVP-KS01/2009 [H1N1]) and monitored for clinical signs, serology, viral shedding, and histopathology. After vaccination, hemagglutination inhibition titre was higher in group D (320) than in the other vaccinated groups (40-80) at the time of challenge. The mobility and feed intake were reduced in group C. Both viral shedding and histopathological lesions were reduced in groups B and D. Although this study has limitation due to the limited number of pigs (2 pigs per a group), the preliminary data in this study provided the protective potential of SL administration of bacteria-expressed pandemic H1N1 influenza vaccine in pigs. There should be additional animal studies about effective adjuvant system and vaccine types for the use of SL influenza vaccination. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MICROBIOLOGICAL SOCIETY KOREA | - |
dc.subject | SWINE-ORIGIN 2009 | - |
dc.subject | VIRUS | - |
dc.subject | RESPONSES | - |
dc.subject | PROTECTION | - |
dc.subject | INFECTION | - |
dc.subject | ADJUVANTS | - |
dc.subject | MICE | - |
dc.title | Preliminary Study about Sublingual Administration of Bacteria-expressed Pandemic H1N1 Influenza Vaccine in Miniature Pigs | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jeong-Ki | - |
dc.contributor.affiliatedAuthor | Song, Daesub | - |
dc.identifier.doi | 10.1007/s12275-014-4289-4 | - |
dc.identifier.scopusid | 2-s2.0-84907073528 | - |
dc.identifier.wosid | 000341060200010 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MICROBIOLOGY, v.52, no.9, pp.794 - 800 | - |
dc.relation.isPartOf | JOURNAL OF MICROBIOLOGY | - |
dc.citation.title | JOURNAL OF MICROBIOLOGY | - |
dc.citation.volume | 52 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 794 | - |
dc.citation.endPage | 800 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001906238 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.subject.keywordPlus | SWINE-ORIGIN 2009 | - |
dc.subject.keywordPlus | VIRUS | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | PROTECTION | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | ADJUVANTS | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordAuthor | pandemic | - |
dc.subject.keywordAuthor | influenza | - |
dc.subject.keywordAuthor | HA1 | - |
dc.subject.keywordAuthor | sublingual vaccine | - |
dc.subject.keywordAuthor | pig | - |
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