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Synthesis and In vivo Evaluation of 5-Methoxy-2-(phenylethynyl)quinoline (MPEQ) and [C-11]MPEQ Targeting Metabotropic Glutamate Receptor 5 (mGluR5)

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dc.contributor.authorKim, Ji Young-
dc.contributor.authorSon, Myung-Hee-
dc.contributor.authorChoi, Kihang-
dc.contributor.authorBaek, Du-Jong-
dc.contributor.authorKo, Min Kyung-
dc.contributor.authorLim, Eun Jeong-
dc.contributor.authorPae, Ae Nim-
dc.contributor.authorKeum, Gyochang-
dc.contributor.authorLee, Jae Kyun-
dc.contributor.authorCho, Yong Seo-
dc.contributor.authorChoo, Hyunah-
dc.contributor.authorLee, Youn Woo-
dc.contributor.authorMoon, Byung Seok-
dc.contributor.authorLee, Byung Cheol-
dc.contributor.authorLee, Ho-Young-
dc.contributor.authorMin, Sun-Joon-
dc.date.accessioned2021-09-05T06:06:49Z-
dc.date.available2021-09-05T06:06:49Z-
dc.date.created2021-06-15-
dc.date.issued2014-08-20-
dc.identifier.issn0253-2964-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/97670-
dc.description.abstractThe synthesis and in vivo evaluation of 5-methoxy-2-(phenylethynyl)quinoline (MPEQ) 3 as a potential mGluR5 selective radioligand is described. We have identified MPEQ 3 exhibiting the analgesic effect in the neuropathic pain animal model. The effect of mGluR5 on neuronal activity in rat brain was evaluated through FDG/PET imaging in the presence of MPEQ 3. In addition, the PET study of [C-11]MPEQ 3 proved that accumulation of [C-11]MPEQ 3 in rat brain was correlated to the localization of the mGluR5.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherWILEY-V C H VERLAG GMBH-
dc.subjectRAT MODEL-
dc.subjectPAIN-
dc.subjectLOCALIZATION-
dc.subjectANTAGONIST-
dc.subjectALLODYNIA-
dc.subjectPET-
dc.titleSynthesis and In vivo Evaluation of 5-Methoxy-2-(phenylethynyl)quinoline (MPEQ) and [C-11]MPEQ Targeting Metabotropic Glutamate Receptor 5 (mGluR5)-
dc.typeArticle-
dc.contributor.affiliatedAuthorChoi, Kihang-
dc.identifier.doi10.5012/bkcs.2014.35.8.2304-
dc.identifier.scopusid2-s2.0-84906351387-
dc.identifier.wosid000340690600014-
dc.identifier.bibliographicCitationBULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.35, no.8, pp.2304 - 2310-
dc.relation.isPartOfBULLETIN OF THE KOREAN CHEMICAL SOCIETY-
dc.citation.titleBULLETIN OF THE KOREAN CHEMICAL SOCIETY-
dc.citation.volume35-
dc.citation.number8-
dc.citation.startPage2304-
dc.citation.endPage2310-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.identifier.kciidART001897371-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.subject.keywordPlusRAT MODEL-
dc.subject.keywordPlusPAIN-
dc.subject.keywordPlusLOCALIZATION-
dc.subject.keywordPlusANTAGONIST-
dc.subject.keywordPlusALLODYNIA-
dc.subject.keywordPlusPET-
dc.subject.keywordAuthorMPEQ-
dc.subject.keywordAuthorMetabotropic glutamate receptor 5 (mGluR5)-
dc.subject.keywordAuthorin vivo-
dc.subject.keywordAuthorPET imaging-
dc.subject.keywordAuthorNeuropathic pain-
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