Enhancement of Tumor-Specific T Cell-Mediated Immunity in Dendritic Cell-Based Vaccines by Mycobacterium tuberculosis Heat Shock Protein X
DC Field | Value | Language |
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dc.contributor.author | Jung, In Duk | - |
dc.contributor.author | Shin, Sung Jae | - |
dc.contributor.author | Lee, Min-Goo | - |
dc.contributor.author | Kang, Tae Heung | - |
dc.contributor.author | Han, Hee Dong | - |
dc.contributor.author | Lee, Seung Jun | - |
dc.contributor.author | Kim, Woo Sik | - |
dc.contributor.author | Kim, Hong Min | - |
dc.contributor.author | Park, Won Sun | - |
dc.contributor.author | Kim, Han Wool | - |
dc.contributor.author | Yun, Cheol-Heui | - |
dc.contributor.author | Lee, Eun Kyung | - |
dc.contributor.author | Wu, T. -C. | - |
dc.contributor.author | Park, Yeong-Min | - |
dc.date.accessioned | 2021-09-05T06:14:03Z | - |
dc.date.available | 2021-09-05T06:14:03Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-08-01 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/97721 | - |
dc.description.abstract | Despite the potential for stimulation of robust antitumor immunity by dendritic cells (DCs), clinical applications of DC-based immunotherapy are limited by the low potency in generating tumor Ag-specific T cell responses. Therefore, optimal conditions for generating potent immunostimulatory DCs that overcome tolerance and suppression are key factors in DC-based tumor immunotherapy. In this study, we demonstrate that use of the Mycobacterium tuberculosis heat shock protein X (HspX) as an immunoadjuvant in DC-based tumor immunotherapy has significant potential in therapeutics. In particular, the treatment aids the induction of tumor-reactive T cell responses, especially tumor-specific CTLs. The HspX protein induces DC maturation and proinflammatory cytokine production (TNF-alpha, IL-1 beta, IL-6, and IFN-beta) through TLR4 binding partially mediated by both the MyD88 and the TRIF signaling pathways. We employed two models of tumor progression and metastasis to evaluate HspX-stimulated DCs in vivo. The administration of HspX-stimulated DCs increased the activation of naive T cells, effectively polarizing the CD4(+) and CD8(+) T cells to secrete IFN-gamma, as well as enhanced the cytotoxicity of splenocytes against HPV-16 E7 (E7)-expressing TC-1 murine tumor cells in therapeutic experimental animals. Moreover, the metastatic capacity of B16-BL6 melanoma cancer cells toward the lungs was remarkably attenuated in mice that received HspX-stimulated DCs. In conclusion, the high therapeutic response rates with tumor-targeted Th1-type T cell immunity as a result of HspX-stimulated DCs in two models suggest that HspX harnesses the exquisite immunological power and specificity of DCs for the treatment of tumors. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER ASSOC IMMUNOLOGISTS | - |
dc.subject | MONOPHOSPHORYL-LIPID-A | - |
dc.subject | ADJUVANT | - |
dc.subject | AGONIST | - |
dc.subject | MATURATION | - |
dc.subject | RESPONSES | - |
dc.subject | INNATE | - |
dc.subject | TLR2 | - |
dc.title | Enhancement of Tumor-Specific T Cell-Mediated Immunity in Dendritic Cell-Based Vaccines by Mycobacterium tuberculosis Heat Shock Protein X | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Min-Goo | - |
dc.identifier.doi | 10.4049/jimmunol.1400656 | - |
dc.identifier.scopusid | 2-s2.0-84906074259 | - |
dc.identifier.wosid | 000339422000029 | - |
dc.identifier.bibliographicCitation | JOURNAL OF IMMUNOLOGY, v.193, no.3, pp.1233 - 1245 | - |
dc.relation.isPartOf | JOURNAL OF IMMUNOLOGY | - |
dc.citation.title | JOURNAL OF IMMUNOLOGY | - |
dc.citation.volume | 193 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 1233 | - |
dc.citation.endPage | 1245 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | MONOPHOSPHORYL-LIPID-A | - |
dc.subject.keywordPlus | ADJUVANT | - |
dc.subject.keywordPlus | AGONIST | - |
dc.subject.keywordPlus | MATURATION | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | INNATE | - |
dc.subject.keywordPlus | TLR2 | - |
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