Tumor-Targeting Multifunctional Nanoparticles for siRNA Delivery: Recent Advances in Cancer Therapy
DC Field | Value | Language |
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dc.contributor.author | Ku, Sook Hee | - |
dc.contributor.author | Kim, Kwangmeyung | - |
dc.contributor.author | Choi, Kuiwon | - |
dc.contributor.author | Kim, Sun Hwa | - |
dc.contributor.author | Kwon, Ick Chan | - |
dc.date.accessioned | 2021-09-05T06:15:41Z | - |
dc.date.available | 2021-09-05T06:15:41Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-08 | - |
dc.identifier.issn | 2192-2640 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/97733 | - |
dc.description.abstract | RNA interference (RNAi) is a naturally occurring regulatory process that controls posttranscriptional gene expression. Small interfering RNA (siRNA), a common form of RNAi-based therapeutics, offers new opportunities for cancer therapy via silencing specific genes, which are associated to cancer progress. However, clinical applications of RNAi-based therapy are still limited due to the easy degradation of siRNA during body circulation and the difficulty in the delivery of siRNA to desired tissues and cells. Thus, there have been many efforts to develop efficient siRNA delivery systems, which protect siRNA from serum nucleases and deliver siRNA to the intracellular region of target cells. Here, the recent advances in siRNA nanocarriers, which possess tumor-targeting ability are reviewed; various nanoparticle systems and their antitumor effects are summarized. The development of multifunctional nanocarriers for theranostics or combinatorial therapy is also discussed. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | MESOPOROUS SILICA NANOPARTICLES | - |
dc.subject | SMALL INTERFERING RNA | - |
dc.subject | OVERCOME DRUG-RESISTANCE | - |
dc.subject | IN-VIVO BIODISTRIBUTION | - |
dc.subject | MEDIATED CO-DELIVERY | - |
dc.subject | LOW-MOLECULAR-WEIGHT | - |
dc.subject | GOLD NANOPARTICLES | - |
dc.subject | SYSTEMIC DELIVERY | - |
dc.subject | TRANSFECTION EFFICIENCY | - |
dc.subject | OXIDE NANOPARTICLES | - |
dc.title | Tumor-Targeting Multifunctional Nanoparticles for siRNA Delivery: Recent Advances in Cancer Therapy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kwon, Ick Chan | - |
dc.identifier.doi | 10.1002/adhm.201300607 | - |
dc.identifier.scopusid | 2-s2.0-84906077659 | - |
dc.identifier.wosid | 000340550500005 | - |
dc.identifier.bibliographicCitation | ADVANCED HEALTHCARE MATERIALS, v.3, no.8, pp.1182 - 1193 | - |
dc.relation.isPartOf | ADVANCED HEALTHCARE MATERIALS | - |
dc.citation.title | ADVANCED HEALTHCARE MATERIALS | - |
dc.citation.volume | 3 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1182 | - |
dc.citation.endPage | 1193 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | MESOPOROUS SILICA NANOPARTICLES | - |
dc.subject.keywordPlus | SMALL INTERFERING RNA | - |
dc.subject.keywordPlus | OVERCOME DRUG-RESISTANCE | - |
dc.subject.keywordPlus | IN-VIVO BIODISTRIBUTION | - |
dc.subject.keywordPlus | MEDIATED CO-DELIVERY | - |
dc.subject.keywordPlus | LOW-MOLECULAR-WEIGHT | - |
dc.subject.keywordPlus | GOLD NANOPARTICLES | - |
dc.subject.keywordPlus | SYSTEMIC DELIVERY | - |
dc.subject.keywordPlus | TRANSFECTION EFFICIENCY | - |
dc.subject.keywordPlus | OXIDE NANOPARTICLES | - |
dc.subject.keywordAuthor | Cancer therapy | - |
dc.subject.keywordAuthor | Multifunctional nanoparticles | - |
dc.subject.keywordAuthor | SiRNA delivery | - |
dc.subject.keywordAuthor | Tumor targeting | - |
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