Antihyperlipidemic Effects of Rhapontin and Rhapontigenin from Rheum undulatum in Rats Fed a High-Cholesterol Diet
DC Field | Value | Language |
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dc.contributor.author | Jo, Sung-Pil | - |
dc.contributor.author | Kim, Jeong-Keun | - |
dc.contributor.author | Lim, Young-Hee | - |
dc.date.accessioned | 2021-09-05T06:18:01Z | - |
dc.date.available | 2021-09-05T06:18:01Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-08 | - |
dc.identifier.issn | 0032-0943 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/97750 | - |
dc.description.abstract | Rhapontin was purified from a methanol extract from the roots of Rheum undulatum, and rhapontigenin was produced by an enzymatic transformation of rhapontin. Rats were fed a high-cholesterol diet to induce hyperlipidemia, followed by oral treatment with rhapontin or rhapontigenin (1-5 mg/kg/day). Rhapontin and rhapontigenin treatment resulted in a significant (p < 0.05) dose-dependent decrease in the serum lipid level, while the high-density lipoprotein cholesterol level increased slightly compared with the experimental control. Furthermore, rhapontin and rhapontigenin treatment improved the pathological characteristics of the degenerating fatty liver in high-cholesterol diet-induced hyperlipidemic rats dose-dependently. Aspartate aminotransferase and alanine aminotransferase levels in rhapontin- and rhapontigenin-treated hyperlipidemic rats were not significantly different from those in the control. These results indicate that rhapontin and rhapontigenin can be used as potent antihyperlipidemic agents. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | GEORG THIEME VERLAG KG | - |
dc.subject | LIPOPROTEINS | - |
dc.subject | ANTICANCER | - |
dc.subject | RHUBARB | - |
dc.subject | MICE | - |
dc.title | Antihyperlipidemic Effects of Rhapontin and Rhapontigenin from Rheum undulatum in Rats Fed a High-Cholesterol Diet | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lim, Young-Hee | - |
dc.identifier.doi | 10.1055/s-0034-1382999 | - |
dc.identifier.scopusid | 2-s2.0-84930491198 | - |
dc.identifier.wosid | 000341581600002 | - |
dc.identifier.bibliographicCitation | PLANTA MEDICA, v.80, no.13, pp.1067 - 1071 | - |
dc.relation.isPartOf | PLANTA MEDICA | - |
dc.citation.title | PLANTA MEDICA | - |
dc.citation.volume | 80 | - |
dc.citation.number | 13 | - |
dc.citation.startPage | 1067 | - |
dc.citation.endPage | 1071 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | LIPOPROTEINS | - |
dc.subject.keywordPlus | ANTICANCER | - |
dc.subject.keywordPlus | RHUBARB | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordAuthor | Rheum undulatum | - |
dc.subject.keywordAuthor | Polygonaceae | - |
dc.subject.keywordAuthor | methoxylated stilbene | - |
dc.subject.keywordAuthor | antihyperlipidemic effect | - |
dc.subject.keywordAuthor | high-cholesterol diet | - |
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