Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Vaccination with ErbB-2 peptides prevents cancer stem cell expansion and suppresses the development of spontaneous tumors in MMTV-PyMT transgenic mice

Authors
Gil, Eun-YoungJo, Uk-HyunLee, Hye JinKang, JinhoSeo, Jae HongLee, Eun SookKim, Yeul HongKim, InSunPhan-Lai, VyDisis, Mary L.Park, Kyong Hwa
Issue Date
8월-2014
Publisher
SPRINGER
Keywords
Breast cancer; ErbB-2; Peptide vaccine; Cancer stem cell; Spontaneous tumor
Citation
BREAST CANCER RESEARCH AND TREATMENT, v.147, no.1, pp.69 - 80
Indexed
SCIE
SCOPUS
Journal Title
BREAST CANCER RESEARCH AND TREATMENT
Volume
147
Number
1
Start Page
69
End Page
80
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/97771
DOI
10.1007/s10549-014-3086-4
ISSN
0167-6806
Abstract
ErbB-2 has been implicated as a target for cancer-initiating cells in breast and other cancers. ErbB-2-directed peptide vaccines have been shown to be effective in prevention of spontaneous tumorigenesis of breast in neu transgenic mouse model, and cellular immunity is proposed as a mechanism for the anti-tumor efficacy. However, there has been no explanation as to how immunity suppresses tumorigenesis from the early stage carcinogenesis, when ErbB-2 expression in breast is low. Here, we investigated a peptide-based vaccine, which consists of two MHC class II epitopes derived from murine ErbB-2, to prevent the occurrence of spontaneous tumors in breast and assess immune impact on breast cancer stem cells. Female MMTV-PyMT transgenic mice were immunized with either ErbB-2 peptide vaccine, or a peptide from tetanus toxoid, or PBS in immune adjuvant. ErbB-2 peptides vaccine completely suppressed spontaneous breast tumors, and the efficacy was correlated with antigen-specific T-cell and antibody responses. In addition, immune serum from the mice of ErbB-2 vaccine group had an inhibitory effect on mammosphere-forming capacity and signaling through ErbB-2 and downstream Akt pathway in ErbB-2 overexpressing mouse mammary cancer cells. We provide evidence that multi-epitope class II peptides vaccine suppresses tumorigenesis of breast potentially by inhibiting the growth of cancer stem cells. We also suggest that a strategy of inducing strong immune responses using multi-epitope ErbB-2-directed helper vaccine might be useful in preventing breast cancer recurrence.
Files in This Item
There are no files associated with this item.
Appears in
Collections
Graduate School > Department of Biomedical Sciences > 1. Journal Articles
College of Medicine > Department of Medical Science > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Seo, Jae Hong photo

Seo, Jae Hong
의과학과
Read more

Altmetrics

Total Views & Downloads

BROWSE