Implication of Circulating Irisin Levels with Brown Adipose Tissue and Sarcopenia in Humans
DC Field | Value | Language |
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dc.contributor.author | Choi, Hae Yoon | - |
dc.contributor.author | Kim, Sungeun | - |
dc.contributor.author | Park, Ji Woo | - |
dc.contributor.author | Lee, Nam Seok | - |
dc.contributor.author | Hwang, Soon Young | - |
dc.contributor.author | Huh, Joo Young | - |
dc.contributor.author | Hong, Ho Cheol | - |
dc.contributor.author | Yoo, Hye Jin | - |
dc.contributor.author | Baik, Sei Hyun | - |
dc.contributor.author | Youn, Byung-Soo | - |
dc.contributor.author | Mantzoros, Christos S. | - |
dc.contributor.author | Choi, Kyung Mook | - |
dc.date.accessioned | 2021-09-05T06:27:36Z | - |
dc.date.available | 2021-09-05T06:27:36Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-08 | - |
dc.identifier.issn | 0021-972X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/97820 | - |
dc.description.abstract | Context: Irisin is an exercise-induced novel myokine that drives brown-fat-like conversion of white adipose tissue and has been suggested to be a promising target for the treatment of obesity-related metabolic disorders. Objective: To assess the association of circulating irisin concentrations with brown adipose tissue (BAT) and/or sarcopenia in humans. Setting and Design: We examined irisin levels in 40 BAT-positive and 40 BAT-negative women detected by F-18-fluorodeoxyglucose positron emission tomography ((18)FDG-PET). In a separate study, we also examined 401 subjects with or without sarcopenia defined by skeletal muscle mass index (SMMI) and appendicular skeletal muscle (ASM)/height(2) using dual-energy x-ray absorptiometry. Results: Among 6877 consecutive 18FDG-PET scans in 4736 subjects, 146 subjects (3.1%) had positive BAT scans. The BAT-detectable group and the matched BAT-undetectable group did not differ in circulating irisin levels measured using two different ELISA kits (P = .747 and P = .160, respectively). Serum irisin levels were not different between individuals with sarcopenia and those without sarcopenia using either kit (P = .305 and P = .569, respectively). Also, serum irisin levels were not different between groups defined by ASM/height(2) using either kit (P = .352 and P = .134, respectively). Although visceral fat area and skeletal muscle mass showed significant difference according to tertiles of SMMI levels, irisin concentrations did not differ. Conclusions: Circulating irisin levels were not different in individuals with detectable BAT or those with sarcopenia compared with control subjects and were not correlated with SMMI. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS INC | - |
dc.subject | FNDC5 GENE-EXPRESSION | - |
dc.subject | SKELETAL-MUSCLE MASS | - |
dc.subject | PREDICTING MORTALITY | - |
dc.subject | PHYSICAL-ACTIVITY | - |
dc.subject | ADULT HUMANS | - |
dc.subject | EXERCISE | - |
dc.subject | OBESITY | - |
dc.subject | FAT | - |
dc.subject | THERMOGENESIS | - |
dc.subject | PGC-1-ALPHA | - |
dc.title | Implication of Circulating Irisin Levels with Brown Adipose Tissue and Sarcopenia in Humans | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Sungeun | - |
dc.contributor.affiliatedAuthor | Yoo, Hye Jin | - |
dc.contributor.affiliatedAuthor | Baik, Sei Hyun | - |
dc.contributor.affiliatedAuthor | Choi, Kyung Mook | - |
dc.identifier.doi | 10.1210/jc.2014-1195 | - |
dc.identifier.scopusid | 2-s2.0-84905836995 | - |
dc.identifier.wosid | 000342341200051 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, v.99, no.8, pp.2778 - 2785 | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | - |
dc.citation.title | JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | - |
dc.citation.volume | 99 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 2778 | - |
dc.citation.endPage | 2785 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | FNDC5 GENE-EXPRESSION | - |
dc.subject.keywordPlus | SKELETAL-MUSCLE MASS | - |
dc.subject.keywordPlus | PREDICTING MORTALITY | - |
dc.subject.keywordPlus | PHYSICAL-ACTIVITY | - |
dc.subject.keywordPlus | ADULT HUMANS | - |
dc.subject.keywordPlus | EXERCISE | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | FAT | - |
dc.subject.keywordPlus | THERMOGENESIS | - |
dc.subject.keywordPlus | PGC-1-ALPHA | - |
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