Neuroprotective Effect of Asiatic Acid in Rat Model of Focal Embolic Stroke
DC Field | Value | Language |
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dc.contributor.author | Lee, Ki Yong | - |
dc.contributor.author | Bae, Ok-Nam | - |
dc.contributor.author | Weinstock, Shelley | - |
dc.contributor.author | Kassab, Mounzer | - |
dc.contributor.author | Majid, Arshad | - |
dc.date.accessioned | 2021-09-05T06:33:05Z | - |
dc.date.available | 2021-09-05T06:33:05Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-08 | - |
dc.identifier.issn | 0918-6158 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/97860 | - |
dc.description.abstract | Asiatic acid (AA) is a pleiotropic neuroprotective agent that has been shown to attenuate infarct volume in mouse and rat models of focal ischemia and has a long clinically relevant therapeutic time-window. Because in a future trial AA would be administered with tissue-plasminogen activator (t-PA), the only approved acute stroke therapy, we sought to determine the effect of AA when co-administered with t-PA in a rat focal embolic stroke model. Male rats were treated with AA (75 mg/kg) alone, low-dose t-PA (2.5 mg/kg) alone, or a combination of AA and low-dose t-PA at 3h after inducing embolic stroke. AA significantly reduced infarct volume whereas low-dose t-PA alone did not reduce infarct volume compared with vehicle. Significantly, combination treatment further enhanced reduction of infarct volume versus AA alone. Treatment with AA reduced cytochrome c (CytoC) and apoptosis-inducing factor (AIF) release from brain mitochondria after ischemia. AA was also neuroprotective against L-glutamate-induced toxicity in primary cortical neurons. In summary, combination treatment with AA and low-dose t-PA at 3h after embolic stroke reduces infarct volume, improves neurological outcome, and provides neuroprotection. The neuroprotective effects of AA were partially associated with reduction of AIF and CytoC release. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PHARMACEUTICAL SOC JAPAN | - |
dc.subject | TISSUE-PLASMINOGEN-ACTIVATOR | - |
dc.subject | ACUTE ISCHEMIC-STROKE | - |
dc.subject | CEREBRAL-ISCHEMIA | - |
dc.subject | PENTACYCLIC TRITERPENE | - |
dc.subject | CENTELLA-ASIATICA | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | INJURY | - |
dc.subject | DERIVATIVES | - |
dc.subject | ENZYMES | - |
dc.subject | UPDATE | - |
dc.title | Neuroprotective Effect of Asiatic Acid in Rat Model of Focal Embolic Stroke | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Ki Yong | - |
dc.identifier.doi | 10.1248/bpb.b14-00055 | - |
dc.identifier.scopusid | 2-s2.0-84906733934 | - |
dc.identifier.wosid | 000339693000019 | - |
dc.identifier.bibliographicCitation | BIOLOGICAL & PHARMACEUTICAL BULLETIN, v.37, no.8, pp.1397 - 1401 | - |
dc.relation.isPartOf | BIOLOGICAL & PHARMACEUTICAL BULLETIN | - |
dc.citation.title | BIOLOGICAL & PHARMACEUTICAL BULLETIN | - |
dc.citation.volume | 37 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1397 | - |
dc.citation.endPage | 1401 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | TISSUE-PLASMINOGEN-ACTIVATOR | - |
dc.subject.keywordPlus | ACUTE ISCHEMIC-STROKE | - |
dc.subject.keywordPlus | CEREBRAL-ISCHEMIA | - |
dc.subject.keywordPlus | PENTACYCLIC TRITERPENE | - |
dc.subject.keywordPlus | CENTELLA-ASIATICA | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordPlus | DERIVATIVES | - |
dc.subject.keywordPlus | ENZYMES | - |
dc.subject.keywordPlus | UPDATE | - |
dc.subject.keywordAuthor | asiatic acid | - |
dc.subject.keywordAuthor | tissue-plasminogen activator (t-PA) | - |
dc.subject.keywordAuthor | neuroprotection | - |
dc.subject.keywordAuthor | rat embolic stroke model | - |
dc.subject.keywordAuthor | stroke | - |
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