ANALYSIS AND INVESTIGATION OF CHEMICAL STABILITY ON PHENOLIC COMPOUNDS IN ZANTHOXYLUM SCHINIFOLIUM-CONTAINING DENTIFRICES

Abstract

Chromatographic properties and chemical stability of 12 kinds of phenolic compounds Z. schinifolium were investigated and analyzed to use as an antioxidant substance in dentifrices. Twelve compounds were completely separated under 0.01% phosphoric acid-acetonitrile gradient condition at 20 degrees C and detected by photodiode array detector. Each compound showed good linearity at optimized wavelength, and showed good precision and accuracy in dentifrices. Using this analytical method, phenolic compounds in Z. schinifolium fraction and dentifrices were successfully determined. Caffeic acid, quercetin, and xanthoxylin decomposed in aqueous solution, and other compounds were preserved over 94%. It was better to store phenolic compounds under weak acidic conditions ( Z. schinifolium -containing dentifrice was manufactured and analyzed. In Z. schinifolium dentifrices, 44% of phenolic compounds remained after 2 mo.