Prevalence and Prognostic Significance of Epstein-Barr Virus Infection in Classical Hodgkin's Lymphoma: A Meta-analysis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Ju-Han | - |
dc.contributor.author | Kim, Younghye | - |
dc.contributor.author | Choi, Jung-Woo | - |
dc.contributor.author | Kim, Young-Sik | - |
dc.date.accessioned | 2021-09-05T07:10:36Z | - |
dc.date.available | 2021-09-05T07:10:36Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-07 | - |
dc.identifier.issn | 0188-4409 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/98005 | - |
dc.description.abstract | Background and Aims. The prevalence and prognostic significance of Epstein-Barr virus (EBV) infection in classical Hodgkin's lymphomas (cHLs) remain elusive. To examine the epidemiological and prognostic differences between EBV-positive and -negative cHLs, we conducted a meta-analysis of 119 published studies including 13,045 cases. Methods. We pooled the results of relevant published studies identified using the PubMed and Embase. The effect sizes of outcome parameters were calculated by prevalence, odds ratio (OR), or hazard ratio using a random-effects model. Results. The pooled prevalence of EBV infection in cHL was 47.9%, which was significantly higher in Africa and Central and South America than other regions. EBV-positive cHL showed higher incidence in children than in adults (69.7 vs. 41.1%). EBV-positive cHL was significantly related to male (OR = 1.8, 95% CI: 1.510-2.038; p <0.001), mixed cellularity subtype (OR = 3.8, 95% CI: 3.243-4.451; p <0.001), and advanced clinical stages (OR = 1.2, 95% CI: 1.072-1.369; p = 0.002). However, the presence of EBV in cHL was not associated with overall or event-free survival. Conclusions. The prevalence of EBV differs according to age, sex, region, histologic subtype, and clinical stage of cHL. However, the presence of EBV has little effects on cHL patient's survival. (C) 2014 IMSS. Published by Elsevier Inc. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.subject | REED-STERNBERG CELLS | - |
dc.subject | LATENT MEMBRANE-PROTEIN | - |
dc.subject | POLYMERASE-CHAIN-REACTION | - |
dc.subject | IN-SITU HYBRIDIZATION | - |
dc.subject | REGULATORY T-CELLS | - |
dc.subject | COMPLEX CLASS-I | - |
dc.subject | HISTOLOGICAL SUBTYPES | - |
dc.subject | INSITU HYBRIDIZATION | - |
dc.subject | FREQUENT EXPRESSION | - |
dc.subject | PRESENTING FEATURES | - |
dc.title | Prevalence and Prognostic Significance of Epstein-Barr Virus Infection in Classical Hodgkin's Lymphoma: A Meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Ju-Han | - |
dc.contributor.affiliatedAuthor | Choi, Jung-Woo | - |
dc.contributor.affiliatedAuthor | Kim, Young-Sik | - |
dc.identifier.doi | 10.1016/j.arcmed.2014.06.001 | - |
dc.identifier.scopusid | 2-s2.0-84904653680 | - |
dc.identifier.wosid | 000340074500009 | - |
dc.identifier.bibliographicCitation | ARCHIVES OF MEDICAL RESEARCH, v.45, no.5, pp.417 - 431 | - |
dc.relation.isPartOf | ARCHIVES OF MEDICAL RESEARCH | - |
dc.citation.title | ARCHIVES OF MEDICAL RESEARCH | - |
dc.citation.volume | 45 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 417 | - |
dc.citation.endPage | 431 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | REED-STERNBERG CELLS | - |
dc.subject.keywordPlus | LATENT MEMBRANE-PROTEIN | - |
dc.subject.keywordPlus | POLYMERASE-CHAIN-REACTION | - |
dc.subject.keywordPlus | IN-SITU HYBRIDIZATION | - |
dc.subject.keywordPlus | REGULATORY T-CELLS | - |
dc.subject.keywordPlus | COMPLEX CLASS-I | - |
dc.subject.keywordPlus | HISTOLOGICAL SUBTYPES | - |
dc.subject.keywordPlus | INSITU HYBRIDIZATION | - |
dc.subject.keywordPlus | FREQUENT EXPRESSION | - |
dc.subject.keywordPlus | PRESENTING FEATURES | - |
dc.subject.keywordAuthor | Hodgkin&apos | - |
dc.subject.keywordAuthor | s lymphoma | - |
dc.subject.keywordAuthor | Epstein-Barr virus | - |
dc.subject.keywordAuthor | Meta-analysis | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.