An inside-out vein graft filled with platelet-rich plasma for repair of a short sciatic nerve defect in rats
- Authors
- Kim, Ji Yeong; Jeon, Woo Joo; Kim, Dong Hwee; Rhyu, Ian Joo; Kim, Young Hwan; Youn, Inchan; Park, Jong Woong
- Issue Date
- 7월-2014
- Publisher
- MEDKNOW PUBLICATIONS & MEDIA PVT LTD
- Keywords
- nerve regeneration; peripheral nerve injury; sciatic nerve; platelet-rich plasma; inside-out vein autograft; myelinated axons; axon diameter; myelin sheath thickness; histology; sciatic nerve index; neural regeneration
- Citation
- NEURAL REGENERATION RESEARCH, v.9, no.14, pp.1351 - 1357
- Indexed
- SCIE
SCOPUS
- Journal Title
- NEURAL REGENERATION RESEARCH
- Volume
- 9
- Number
- 14
- Start Page
- 1351
- End Page
- 1357
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/98108
- DOI
- 10.4103/1673-5374.137587
- ISSN
- 1673-5374
- Abstract
- Platelet-rich plasma containing various growth factors can promote nerve regeneration. An inside-out vein graft can substitute nerve autograft to repair short nerve defects. It is hypothesized that an inside-out vein graft filled with platelet-rich plasma shows better effects in the repair of short sciatic nerve defects. In this study, an inside-out vein autograft filled with platelet-rich plasma was used to bridge a 10 mm-long sciatic nerve defect in rats. The sciatic nerve function of rats with an inside-out vein autograft filled with platelet-rich plasma was better improved than that of rats with a simple inside-out vein autograft. At 6 and 8 weeks, the sciatic nerve function of rats with an inside-out vein autograft filled with platelet-rich plasma was better than that of rats undergoing nerve autografting. Compared with the sciatic nerve repaired with a simple inside-out vein autograft, the number of myelinated axons was higher, axon diameter and myelin sheath were greater in the sciatic nerve repaired with an inside-out vein autograft filled with platelet-rich plasma and they were similar to those, in the sciatic nerve repaired with nerve autograft. These findings suggest that an inside-out vein graft filled with platelet-rich plasma can substitute nerve autograft to repair short sciatic nerve defects.
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- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
- Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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