Immune-mediated tumor evolution: Nanog links the emergence of a stem like cancer cell state and immune evasion
DC Field | Value | Language |
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dc.contributor.author | Mao, Chih-Ping | - |
dc.contributor.author | Wu, T. C. | - |
dc.contributor.author | Song, Kwon-Ho | - |
dc.contributor.author | Kim, Tae Woo | - |
dc.date.accessioned | 2021-09-05T07:30:28Z | - |
dc.date.available | 2021-09-05T07:30:28Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-07 | - |
dc.identifier.issn | 2162-4011 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/98145 | - |
dc.description.abstract | Tumor cells undergo molecular evolution under immune pressure. Using a murine metastatic lung cancer model, we recently reported that evolutionary pressure enforced through vaccination incites gain of Nanog, a master transcription factor that mediates both emergence of a stem-like cancer cell state and immune evasion. Thus, therapeutic strategies aiming to blunt NANOG's expression in patient tumors may improve the clinical management of cancer. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS INC | - |
dc.subject | SURVIVAL | - |
dc.subject | AKT | - |
dc.subject | EXPRESSION | - |
dc.title | Immune-mediated tumor evolution: Nanog links the emergence of a stem like cancer cell state and immune evasion | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Tae Woo | - |
dc.identifier.doi | 10.4161/21624011.2014.947871 | - |
dc.identifier.scopusid | 2-s2.0-84911372296 | - |
dc.identifier.wosid | 000346921100014 | - |
dc.identifier.bibliographicCitation | ONCOIMMUNOLOGY, v.3, no.7 | - |
dc.relation.isPartOf | ONCOIMMUNOLOGY | - |
dc.citation.title | ONCOIMMUNOLOGY | - |
dc.citation.volume | 3 | - |
dc.citation.number | 7 | - |
dc.type.rims | ART | - |
dc.type.docType | Editorial Material | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | AKT | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordAuthor | cytotoxic T lymphocytes | - |
dc.subject.keywordAuthor | immune-resistant | - |
dc.subject.keywordAuthor | immune surveillance | - |
dc.subject.keywordAuthor | Nanog | - |
dc.subject.keywordAuthor | stem-like phenotype | - |
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