Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Working memory deficit in patients with restless legs syndrome: an event-related potential study

Authors
Kim, Sung MinChoi, Jeong WooLee, ChanyLee, Byeong UkKoo, Yong SeoKim, Kyung HwanJung, Ki-Young
Issue Date
7월-2014
Publisher
ELSEVIER
Keywords
Restless legs syndrome; Working memory; Cognition disorders; Event-related potential; P300; Frontal lobe
Citation
SLEEP MEDICINE, v.15, no.7, pp.808 - 815
Indexed
SCIE
SCOPUS
Journal Title
SLEEP MEDICINE
Volume
15
Number
7
Start Page
808
End Page
815
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/98164
DOI
10.1016/j.sleep.2014.03.010
ISSN
1389-9457
Abstract
Objective: The aim of this study was to investigate whether there is a working memory (WM) deficit in restless legs syndrome (RLS) patients, by studying the Sternberg WM task of event-related potential (ERP). Methods: Thirteen drug-naive RLS patients and 13 healthy age-matched controls with no sleep disturbances participated in the present study. P300 ERP was recorded during Sternberg WM task using digits as mnemonic items. P300 amplitudes and reaction times were compared between groups (RLS vs control) considering brain regions (frontal, central, and parietal) and memory load sizes (two, three, and four) as within-subject factors. Clinical and sleep-related variables were correlated with P300 amplitude. Results: The reaction time in RLS patients was significantly longer than controls over all memory load sizes. The P300 amplitude at parietal regions in RLS patients was significantly lower than in controls regardless of memory load sizes, which was significantly negatively correlated with duration of RLS history in RLS patients. Conclusion: Our study suggests that patients with severe RLS have WM deficits. Furthermore, negative correlation of P300 amplitudes with the duration of RLS illness suggests that cerebral cortical dysfunction in RLS patients results from repeated RLS symptom attacks. (C) 2014 Elsevier B.V. All rights reserved.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medical Science > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE