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Gadolinium-based nanoparticles for highly efficient T1-weighted magnetic resonance imaging

Authors
Lim, Eun-KyungKang, ByunghoonChoi, YunaJang, EunjiHan, SeungminLee, KwangyeolSuh, Jin-SuckHaam, SeungjooHuh, Yong-Min
Issue Date
20-6월-2014
Publisher
IOP PUBLISHING LTD
Keywords
magnetic resonance image; imaging agent; gadolinium; high sensitivity
Citation
NANOTECHNOLOGY, v.25, no.24
Indexed
SCIE
SCOPUS
Journal Title
NANOTECHNOLOGY
Volume
25
Number
24
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/98212
DOI
10.1088/0957-4484/25/24/245103
ISSN
0957-4484
Abstract
We developed Pyrene-Gadolinium (Py-Gd) nanoparticles as pH-sensitive magnetic resonance imaging (MRI) contrast agents capable of showing a high-Mr signal in cancer-specific environments, such as acidic conditions. Py-Gd nanoparticles were prepared by coating Py-Gd, which is a complex of gadolinium with pyrenyl molecules, with pyrenyl polyethyleneglycol PEG using a nano-emulsion method. These particles show better longitudinal relaxation time (T1) MR signals in acidic conditions than they do in neutral conditions. Furthermore, the particles exhibit biocompatibility and MR contrast effects in both in vitro and in vivo studies. From these results, we confirm that Py-Gd nanoparticles have the potential to be applied for accurate cancer diagnosis and therapy.
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