Effects of Group 1 versus Group 2 Carbapenems on the Susceptibility of Acinetobacter baumannii to Carbapenems: A Before and After Intervention Study of Carbapenem-Use Stewardship
DC Field | Value | Language |
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dc.contributor.author | Yoon, Young Kyung | - |
dc.contributor.author | Yang, Kyung Sook | - |
dc.contributor.author | Lee, Seung Eun | - |
dc.contributor.author | Kim, Hyun Jeong | - |
dc.contributor.author | Sohn, Jang Wook | - |
dc.contributor.author | Kim, Min Ja | - |
dc.date.accessioned | 2021-09-05T07:55:43Z | - |
dc.date.available | 2021-09-05T07:55:43Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-06-09 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/98247 | - |
dc.description.abstract | Objective: Antimicrobial stewardship programs have been proposed for reducing bacterial resistance in the hospital environment. The purpose of this study was to investigate the impact of a carbapenem-use stewardship program on the susceptibility of Acinetobacter baumannii to Group 2 carbapenems. Methods: A before and after intervention study was conducted at a university hospital from September 2008 to February 2013. Three study periods were defined: Phase I, pre-intervention (months 1-18); Phase II, a postintervention period during which ertapenem use was mandated but carbapenem use was not restricted (months 19-36); and Phase III, a postintervention period during which Group 2 carbapenem use was restricted (months 37-54). Results: During the study period, intervention resulted in diminished consumption of Group 2 carbapenems (antimicrobial use density (AUD): 21.3 +/- 6.0 in Phase I, 18.8 +/- 6.0 in Phase II, 16.1 +/- 4.4 in Phase III; P = 0.028) and increased consumption of ertapenem (AUD: 2.7 +/- 1.7 in Phase I, 7.2 +/- 4.5 in Phase II, 9.1 +/- 5.3 in Phase III; P<0.001). The use of autoregressive-error models showed that in contrast with ertapenem use, the use of Group 2 carbapenem during the previous one month was positively and significantly associated with a subsequent increase in the proportion of carbapenem-resistant A. baumannii (CRAB) (P = 0.031). Conclusions: Implementing a carbapenem-use stewardship program featuring the preferential use of ertapenem for treating appropriate indications of infection resulted in reduced use of Group 2 carbapenems and had a positive impact on the susceptibility of A. baumannii to carbapenems. This approach could be integrated into CRAB-control strategies in hospitals. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.subject | PSEUDOMONAS-AERUGINOSA | - |
dc.subject | KLEBSIELLA-PNEUMONIAE | - |
dc.subject | ERTAPENEM USE | - |
dc.subject | ANTIMICROBIAL RESISTANCE | - |
dc.subject | MULTIDRUG-RESISTANCE | - |
dc.subject | HOSPITAL ECOLOGY | - |
dc.subject | IMPACT | - |
dc.subject | IMIPENEM | - |
dc.subject | CONSUMPTION | - |
dc.subject | BACTEREMIA | - |
dc.title | Effects of Group 1 versus Group 2 Carbapenems on the Susceptibility of Acinetobacter baumannii to Carbapenems: A Before and After Intervention Study of Carbapenem-Use Stewardship | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yoon, Young Kyung | - |
dc.contributor.affiliatedAuthor | Sohn, Jang Wook | - |
dc.contributor.affiliatedAuthor | Kim, Min Ja | - |
dc.identifier.doi | 10.1371/journal.pone.0099101 | - |
dc.identifier.scopusid | 2-s2.0-84902593557 | - |
dc.identifier.wosid | 000337165600043 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.9, no.6 | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 9 | - |
dc.citation.number | 6 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | PSEUDOMONAS-AERUGINOSA | - |
dc.subject.keywordPlus | KLEBSIELLA-PNEUMONIAE | - |
dc.subject.keywordPlus | ERTAPENEM USE | - |
dc.subject.keywordPlus | ANTIMICROBIAL RESISTANCE | - |
dc.subject.keywordPlus | MULTIDRUG-RESISTANCE | - |
dc.subject.keywordPlus | HOSPITAL ECOLOGY | - |
dc.subject.keywordPlus | IMPACT | - |
dc.subject.keywordPlus | IMIPENEM | - |
dc.subject.keywordPlus | CONSUMPTION | - |
dc.subject.keywordPlus | BACTEREMIA | - |
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