Identification of Lactoferrin as a Human Dedifferentiation Factor Through the Studies of Reptile Tissue Regeneration Mechanisms
DC Field | Value | Language |
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dc.contributor.author | Bae, Kil Soo | - |
dc.contributor.author | Kim, Sun Young | - |
dc.contributor.author | Park, Soon Yong | - |
dc.contributor.author | Jeong, Ae Jin | - |
dc.contributor.author | Lee, Hyun Hee | - |
dc.contributor.author | Lee, Jungwoon | - |
dc.contributor.author | Cho, Yee Sook | - |
dc.contributor.author | Leem, Sun-Hee | - |
dc.contributor.author | Kang, Tae-Hong | - |
dc.contributor.author | Bae, Kwang-Hee | - |
dc.contributor.author | Kim, Jae Ho | - |
dc.contributor.author | Jung, Yong Woo | - |
dc.contributor.author | Jun, Woojin | - |
dc.contributor.author | Yoon, Suk Ran | - |
dc.contributor.author | Lee, Sang-Chul | - |
dc.contributor.author | Chung, Jin Woong | - |
dc.date.accessioned | 2021-09-05T08:09:05Z | - |
dc.date.available | 2021-09-05T08:09:05Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-06 | - |
dc.identifier.issn | 1017-7825 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/98276 | - |
dc.description.abstract | In this study, we performed two-dimensional electrophoresis with protein extracts from lizard tails, and analyzed the protein expression profiles during the tissue regeneration to identify the dedifferentiation factor. As a result, we identified 18 protein spots among total of 292 spots, of which proteins were specifically expressed during blastema formation. We selected lactoferrin as a candidate because it is the mammalian homolog of leech-derived tryptase inhibitor, which showed the highest frequency among the 18 proteins. Lactoferrin was specifically expressed in various stem cell lines, and enhanced the efficiency of iPSC generation upto approximately 7-fold relative to the control. Furthermore, lactoferrin increased the efficiency by 2-fold without enforced expression of Klf4. These results suggest that lactoferrin may induce dedifferentiation, at least partly by increasing the expression of Klf4. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY | - |
dc.subject | PLURIPOTENT STEM-CELLS | - |
dc.subject | TRYPTASE INHIBITOR | - |
dc.subject | LEOPARD GECKO | - |
dc.subject | INDUCTION | - |
dc.subject | PROLIFERATION | - |
dc.subject | GENERATION | - |
dc.subject | MOUSE | - |
dc.subject | MODEL | - |
dc.subject | MYC | - |
dc.title | Identification of Lactoferrin as a Human Dedifferentiation Factor Through the Studies of Reptile Tissue Regeneration Mechanisms | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jung, Yong Woo | - |
dc.identifier.doi | 10.4014/jmb.1402.02009 | - |
dc.identifier.scopusid | 2-s2.0-84902583692 | - |
dc.identifier.wosid | 000338177600018 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v.24, no.6, pp.869 - 878 | - |
dc.relation.isPartOf | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | - |
dc.citation.title | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | - |
dc.citation.volume | 24 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 869 | - |
dc.citation.endPage | 878 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001887904 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.subject.keywordPlus | PLURIPOTENT STEM-CELLS | - |
dc.subject.keywordPlus | TRYPTASE INHIBITOR | - |
dc.subject.keywordPlus | LEOPARD GECKO | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | GENERATION | - |
dc.subject.keywordPlus | MOUSE | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | MYC | - |
dc.subject.keywordAuthor | Dedifferentiation | - |
dc.subject.keywordAuthor | iPSCs | - |
dc.subject.keywordAuthor | lactoferrin | - |
dc.subject.keywordAuthor | stem cell | - |
dc.subject.keywordAuthor | tissue regeneration | - |
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