Photodynamic therapy by in situ nonlinear photon conversion
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kachynski, A. V. | - |
dc.contributor.author | Pliss, A. | - |
dc.contributor.author | Kuzmin, A. N. | - |
dc.contributor.author | Ohulchanskyy, T. Y. | - |
dc.contributor.author | Baev, A. | - |
dc.contributor.author | Qu, J. | - |
dc.contributor.author | Prasad, P. N. | - |
dc.date.accessioned | 2021-09-05T08:10:58Z | - |
dc.date.available | 2021-09-05T08:10:58Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-06 | - |
dc.identifier.issn | 1749-4885 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/98287 | - |
dc.description.abstract | In photodynamic therapy, light is absorbed by a therapy agent (photosensitizer) to generate reactive oxygen, which then locally kills diseased cells. Here, we report a new form of photodynamic therapy in which nonlinear optical interactions of near-infrared laser radiation with a biological medium in situ produce light that falls within the absorption band of the photosensitizer. The use of near-infrared radiation, followed by upconversion to visible or ultraviolet light, provides deep tissue penetration, thus overcoming a major hurdle in treatment. By modelling and experiment, we demonstrate activation of a known photosensitizer, chlorin e6, by in situ nonlinear optical upconversion of near-infrared laser radiation using second-harmonic generation in collagen and four-wave mixing, including coherent anti-Stokes Raman scattering, produced by cellular biomolecules. The introduction of coherent anti-Stokes Raman scattering/four-wave mixing to photodynamic therapy in vitro increases the efficiency by a factor of two compared to two-photon photodynamic therapy alone, while second-harmonic generation provides a fivefold increase. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | SINGLET OXYGEN | - |
dc.subject | PHOTOSENSITIZERS | - |
dc.subject | GENERATION | - |
dc.subject | VIVO | - |
dc.subject | NANOPARTICLES | - |
dc.subject | PORPHYRIN | - |
dc.subject | COLLAGEN | - |
dc.subject | VITRO | - |
dc.title | Photodynamic therapy by in situ nonlinear photon conversion | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Prasad, P. N. | - |
dc.identifier.doi | 10.1038/nphoton.2014.90 | - |
dc.identifier.scopusid | 2-s2.0-84901688744 | - |
dc.identifier.wosid | 000336972000011 | - |
dc.identifier.bibliographicCitation | NATURE PHOTONICS, v.8, no.6, pp.455 - 461 | - |
dc.relation.isPartOf | NATURE PHOTONICS | - |
dc.citation.title | NATURE PHOTONICS | - |
dc.citation.volume | 8 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 455 | - |
dc.citation.endPage | 461 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Optics | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Optics | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.subject.keywordPlus | SINGLET OXYGEN | - |
dc.subject.keywordPlus | PHOTOSENSITIZERS | - |
dc.subject.keywordPlus | GENERATION | - |
dc.subject.keywordPlus | VIVO | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | PORPHYRIN | - |
dc.subject.keywordPlus | COLLAGEN | - |
dc.subject.keywordPlus | VITRO | - |
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