A meta-analysis of the relationship between aspartic acid (D)-repeat polymorphisms in asporin and osteoarthritis susceptibility
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Song, Gwan Gyu | - |
dc.contributor.author | Kim, Jae-Hoon | - |
dc.contributor.author | Lee, Young Ho | - |
dc.date.accessioned | 2021-09-05T08:12:15Z | - |
dc.date.available | 2021-09-05T08:12:15Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-06 | - |
dc.identifier.issn | 0172-8172 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/98295 | - |
dc.description.abstract | Our aim was to determine whether asporin (ASPN) D-repeat polymorphisms are associated with susceptibility to osteoarthritis (OA). A meta-analysis was conducted to examine the association between the ASPN D14, D13, and D15 alleles and OA of the knee and hip in each ethnic group. In total, 9 studies from eight articles involving 4,417 OA patients and 3,403 controls were considered in the meta-analysis. Meta-analysis showed no association between OA and the ASPN allele coding for 14 D-repeats (D14) in the overall population (OR 1.161, 95 % CI 0.934-1.444, p = 0.178). Stratification by ethnicity identified no association between the ASPN D14 allele and OA in Europeans or Asians (OR 1.035, 95 % CI 0.914-1.173, p = 0.589; OR 1.537, 95 % CI 0.899-2.626, p = 0.116), respectively. However, high heterogeneity was found in Asians (I (2) = 81.2, p = 0.001). Meta-analysis of OA by site showed no association between knee and hip OA and the ASPN D14 allele (OR 1.240, 95 % CI 0.946-1.627, p = 0.119; OR 1.130, 95 % CI 0.767-1.665, p = 0.537). Meta-analysis of D14 versus D13 allele showed the same pattern of OA association as the D14 allele. No association was found between the ASPN D13 and D15 alleles and risk of developing OA by meta-analysis (OR 0.942, 95 % CI 0.840-1.056, p = 0.304; OR 1.050, 95 % CI 0.956-1.154, p = 0.306), respectively. This meta-analysis shows that the ASPN D14, D13, and D15 alleles are not associated with the development of OA in Europeans and Asians. Thus, further study of this relationship is required in homogenous populations because of the heterogeneity of the ASPN D14 allele observed in Asians. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER HEIDELBERG | - |
dc.subject | REPEAT POLYMORPHISM | - |
dc.subject | KNEE-OSTEOARTHRITIS | - |
dc.subject | HAN CHINESE | - |
dc.subject | ASSOCIATION | - |
dc.subject | GENE | - |
dc.subject | POPULATION | - |
dc.subject | ASPN | - |
dc.subject | CAUCASIANS | - |
dc.subject | LOCI | - |
dc.title | A meta-analysis of the relationship between aspartic acid (D)-repeat polymorphisms in asporin and osteoarthritis susceptibility | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.identifier.doi | 10.1007/s00296-013-2916-8 | - |
dc.identifier.scopusid | 2-s2.0-84901604393 | - |
dc.identifier.wosid | 000336285200006 | - |
dc.identifier.bibliographicCitation | RHEUMATOLOGY INTERNATIONAL, v.34, no.6, pp.785 - 792 | - |
dc.relation.isPartOf | RHEUMATOLOGY INTERNATIONAL | - |
dc.citation.title | RHEUMATOLOGY INTERNATIONAL | - |
dc.citation.volume | 34 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 785 | - |
dc.citation.endPage | 792 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | REPEAT POLYMORPHISM | - |
dc.subject.keywordPlus | KNEE-OSTEOARTHRITIS | - |
dc.subject.keywordPlus | HAN CHINESE | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordPlus | ASPN | - |
dc.subject.keywordPlus | CAUCASIANS | - |
dc.subject.keywordPlus | LOCI | - |
dc.subject.keywordAuthor | Osteoarthritis | - |
dc.subject.keywordAuthor | Asporin | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | Meta-analysis | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.