Cytotoxicity of a novel mineral trioxide aggregated-based root canal sealer
- Authors
- Kim, Ryan Jin Young; Shin, Joo Hee
- Issue Date
- 6월-2014
- Publisher
- JAPANESE SOC DENTAL MATERIALS DEVICES
- Keywords
- Cell adhesion; Cytotoxicity; Mineral trioxide aggregate; Root canal sealers; WST-1
- Citation
- DENTAL MATERIALS JOURNAL, v.33, no.3, pp.313 - 318
- Indexed
- SCIE
SCOPUS
- Journal Title
- DENTAL MATERIALS JOURNAL
- Volume
- 33
- Number
- 3
- Start Page
- 313
- End Page
- 318
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/98300
- DOI
- 10.4012/dmj.2013-171
- ISSN
- 0287-4547
- Abstract
- The objective of this study was to assess the cytotoxicity of EndoSeal, a novel mineral trioxide aggregate-based root canal sealer in comparison with two commonly used sealers All Plus and Sealapex. For cytotoxicity assay, MG-63 cells and human gingival fibroblasts were incubated in culture medium containing eluates of each sealer at 1, 3, and 7 days. Cell metabolism was evaluated by the WST-1 assay. For cell adhesion assay, disc specimens were fabricated from EndoSeal and AH Plus. MG-63 cells and human gingival fibroblasts were seeded on the discs, and after 1 day and 7 days of incubation, cell morphology and cell adhesion were examined by SEM. The order of cytotoxicity of root canal sealers was as follows: EndoSeal < AH Plus < Sealapex. Both types of cells seeded on the EndoSeal specimens were much larger, flat with rough margins compared to those on the AH Plus specimens. These results suggest that EndoSeal has a satisfactory cytocompatibility.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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