Enhanced effects of osteoclastogenesis inhibition by curcumin-delivering heparin nanoparticles
- Authors
- Yun, Young-Pil; Kim, Sung Eun; Lee, Jae Yong; Kim, Hak-Jun; Choi, Sung-Wook; Song, Hae-Ryong; Park, Kyeongsoon
- Issue Date
- 6월-2014
- Publisher
- POLYMER SOC KOREA
- Keywords
- curcumin; heparin nanoparticles; osteoclast; osteoclastogenesis; RANKL
- Citation
- MACROMOLECULAR RESEARCH, v.22, no.6, pp.647 - 656
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- MACROMOLECULAR RESEARCH
- Volume
- 22
- Number
- 6
- Start Page
- 647
- End Page
- 656
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/98324
- DOI
- 10.1007/s13233-014-2082-1
- ISSN
- 1598-5032
- Abstract
- Curcumin has various pharmacological activities such as anti-inflammatory, antioxidant, antimicrobial and antitumor activity. However, its use has been limited due to its poor solubility in water and minimal systemic bioavailability. Thus, we developed curcumin-delivering heparin-based nanoparticles and evaluated the inhibition effects of osteoclastogenesis by curcumin-delivering heparin nanoparticles (Cur-HD NPs). Cur-HD NPs were dispersed well in aqueous solution by forming self-assembled nanoparticles and showed sustained release of curcumin. In vitro studies, HD NPs facilitated intracellular delivery of curcumin into macrophages and osteoclasts, and thus, Cur-HD NPs effectively inhibited osteoclastogenesis in a dose-dependent manner by suppressing tartrate-resistant acid phosphatase (TRAP) activity and TRAP-positive multinucleated cells as well as by reducing the expression of osteoclast marker genes (i.e., TRAP and nuclear factor of activated T cells cytoplasmic 1 (NFATc1)). Furthermore, Cur-HD NPs markedly stimulated apoptosis of osteoclasts. Therefore, we hope that Cur-HD NPs will be useful nanodrugs for the treatment of bone-related diseases.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
- Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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