Diverse Influences of Androgen-Disrupting Chemicals on Immune Responses Mounted by Macrophages
- Authors
- Kim, Kyong Hoon; Yeon, Seung-min; Kim, Hyun Gyung; Choi, Hyun Suk; Kang, Hyojeung; Park, Hee-Deung; Park, Tae Won; Pack, Seung Pil; Lee, Eun Hee; Byun, Youngjoo; Choi, Sang-Eun; Lee, Kenneth Sung; Ha, Un-Hwan; Jung, Yong Woo
- Issue Date
- 6월-2014
- Publisher
- SPRINGER/PLENUM PUBLISHERS
- Keywords
- androgen-disrupting chemicals; macrophage; lipopolysaccharide; nitric oxide; cell death
- Citation
- INFLAMMATION, v.37, no.3, pp.649 - 656
- Indexed
- SCIE
SCOPUS
- Journal Title
- INFLAMMATION
- Volume
- 37
- Number
- 3
- Start Page
- 649
- End Page
- 656
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/98327
- DOI
- 10.1007/s10753-013-9781-1
- ISSN
- 0360-3997
- Abstract
- Androgen-disrupting chemicals (ADCs) can alter male sexual development. Although the effects of ADCs on hormone disruption have been studied, their influence on the immune response is not fully understood. To investigate the effects of ADCs on innate immunity, we tested eight candidate ADCs for their influence on macrophages by measuring nitric oxide (NO) production and cell viability. Our results showed that treatment with a mixture of lipopolysaccharide and hexachlorobenzene increased NO production in RAW 264.7 cells, a murine macrophage cell line. In contrast, compared to exposure to a negative control, exposure to di-2-ethylhexyl adipate (DEHA), benzylbutyl phthalate (BBP), testosterone (TTT), or permethrin decreased NO production. DEHA, BBP, and TTT inhibited NO production in an inducible nitric oxide synthase-dependent manner. Treatment with bisphenol A (BPA), nonylphenol (NNP), or tributyltin chloride (TBTC) reduced NO production and induced cell death. While BPA induced RAW 264.7 cell death through apoptosis, NNP and TBTC caused cell death through necrosis. These results offer insights into the influences of ADCs on the innate immune system.
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Collections - College of Engineering > School of Civil, Environmental and Architectural Engineering > 1. Journal Articles
- Graduate School > Department of Biotechnology and Bioinformatics > 1. Journal Articles
- College of Pharmacy > Department of Pharmaceutical Science > 1. Journal Articles
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