Comparison of the Effects of 0.03 and 0.05 mg/kg Midazolam with Placebo on Prevention of Emergence Agitation in Children Having Strabismus Surgery
DC Field | Value | Language |
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dc.contributor.author | Cho, Eun Jung | - |
dc.contributor.author | Yoon, Seung Zhoo | - |
dc.contributor.author | Cho, Jang Eun | - |
dc.contributor.author | Lee, Hye Won | - |
dc.date.accessioned | 2021-09-05T08:23:00Z | - |
dc.date.available | 2021-09-05T08:23:00Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-06 | - |
dc.identifier.issn | 0003-3022 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/98366 | - |
dc.description.abstract | Background: Midazolam has been widely studied for preventing emergence agitation. The authors previously reported that in children with sevoflurane anesthesia, intravenous administration of midazolam (0.05 mg/kg) before the end of surgery reduced the incidence of emergence agitation but prolonged the emergence time. This study was designed to test the hypothesis that a lower midazolam dose could suppress emergence agitation with minimal disturbance of the emergence time in children with sevoflurane anesthesia. Methods: In this randomized, double-blind, placebo-controlled trial, 90 children (1 to 13 yr of age) having strabismus surgery were randomized to 1: 1: 1 to receive 0.03 mg/kg of midazolam, 0.05 mg/kg of midazolam, or saline just before the end of surgery. The primary outcome, the incidence of emergence agitation, was evaluated by using the pediatric anesthesia emergence delirium scale and the four-point agitation scale. The secondary outcome was time to emergence, defined as the time from sevoflurane discontinuation to the time to extubation. Results: The incidence of emergence agitation was lower in patients given 0.03 mg/kg of midazolam (5 of 30, 16.7%) and patients given 0.05 mg/kg of midazolam (5 of 30, 16.7%) compared with that in patients given saline (13/of 30, 43.3%; P = 0.036 each). The emergence time was longer in patients given 0.05 mg/kg of midazolam (17.1 +/- 3.4 min, mean +/- SD) compared with that in patients given 0.03 mg/kg of midazolam (14.1 +/- 3.6 min; P = 0.0009) or saline (12.8 +/- 4.1 min; P = 0.0003). Conclusion: Intravenous administration of 0.03 mg/kg of midazolam just before the end of surgery reduces emergence agitation without delaying the emergence time in children having strabismus surgery with sevoflurane anesthesia. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.subject | SEVOFLURANE ANESTHESIA | - |
dc.subject | DESFLURANE ANESTHESIA | - |
dc.subject | GENERAL-ANESTHESIA | - |
dc.subject | DELIRIUM SCALE | - |
dc.subject | FENTANYL | - |
dc.subject | PROPOFOL | - |
dc.subject | ADENOTONSILLECTOMY | - |
dc.subject | HALOTHANE | - |
dc.subject | RECOVERY | - |
dc.subject | REDUCE | - |
dc.title | Comparison of the Effects of 0.03 and 0.05 mg/kg Midazolam with Placebo on Prevention of Emergence Agitation in Children Having Strabismus Surgery | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yoon, Seung Zhoo | - |
dc.contributor.affiliatedAuthor | Cho, Jang Eun | - |
dc.contributor.affiliatedAuthor | Lee, Hye Won | - |
dc.identifier.doi | 10.1097/ALN.0000000000000181 | - |
dc.identifier.scopusid | 2-s2.0-84901620501 | - |
dc.identifier.wosid | 000337753900010 | - |
dc.identifier.bibliographicCitation | ANESTHESIOLOGY, v.120, no.6, pp.1354 - 1361 | - |
dc.relation.isPartOf | ANESTHESIOLOGY | - |
dc.citation.title | ANESTHESIOLOGY | - |
dc.citation.volume | 120 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1354 | - |
dc.citation.endPage | 1361 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Anesthesiology | - |
dc.relation.journalWebOfScienceCategory | Anesthesiology | - |
dc.subject.keywordPlus | SEVOFLURANE ANESTHESIA | - |
dc.subject.keywordPlus | DESFLURANE ANESTHESIA | - |
dc.subject.keywordPlus | GENERAL-ANESTHESIA | - |
dc.subject.keywordPlus | DELIRIUM SCALE | - |
dc.subject.keywordPlus | FENTANYL | - |
dc.subject.keywordPlus | PROPOFOL | - |
dc.subject.keywordPlus | ADENOTONSILLECTOMY | - |
dc.subject.keywordPlus | HALOTHANE | - |
dc.subject.keywordPlus | RECOVERY | - |
dc.subject.keywordPlus | REDUCE | - |
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