Slow injection of nefopam reduces pain intensity associated with intravenous injection: a prospective randomized trial
DC Field | Value | Language |
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dc.contributor.author | Kim, Young Min | - |
dc.contributor.author | Lim, Byung Gun | - |
dc.contributor.author | Kim, Heezoo | - |
dc.contributor.author | Kong, Myoung Hoon | - |
dc.contributor.author | Lee, Mi Kyoung | - |
dc.contributor.author | Lee, Il Ok | - |
dc.date.accessioned | 2021-09-05T08:25:51Z | - |
dc.date.available | 2021-09-05T08:25:51Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-06 | - |
dc.identifier.issn | 0913-8668 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/98386 | - |
dc.description.abstract | We aimed to investigate the frequency and severity of pain associated with intravenous injection of nefopam and to determine whether a slow rate of administration can effectively reduce such pain. We used a solution containing 30 mg nefopam diluted to 20 ml in saline. In all, 102 adult patients undergoing minor surgery were randomly allocated to one of three administration groups: A (60 ml/h, n = 34); B (120 ml/h, n = 34); or C (180 ml/h, n = 34). All patients scored the maximal pain experienced during the 120-s infusion period, using the visual analogue scale (VAS) and the verbal pain score (VPS). Adverse events including phlebitis were recorded. Eighty-three patients (29 in group A, 27 each in groups B and C) were included in the final analysis. The incidence of injection pain was lower in group A (86.2 %) than in groups B (96.3 %) and C (100 %), but this difference was not statistically significant. The proportion of patients with a tolerable level of pain (VAS 0-3 and VPS 0-1) was significantly higher in group A (79.3 %) versus groups B (7.4 %) and C (3.7 %). The mean VAS scores for groups A, B, and C were 2.2 +/- A 1.3, 5.1 +/- A 1.6, and 7.2 +/- A 1.7, respectively, and these differences were statistically significant. At the slower rate of infusion (60 ml/h) of the 1.5 mg/ml nefopam solution, injection pain intensity was attenuated to a significantly greater degree than at the faster rates. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER JAPAN KK | - |
dc.subject | POSTOPERATIVE PAIN | - |
dc.subject | MORPHINE | - |
dc.subject | MIDAZOLAM | - |
dc.subject | PROPOFOL | - |
dc.subject | ANALOG | - |
dc.subject | KETOPROFEN | - |
dc.subject | ANALGESIA | - |
dc.subject | SCALE | - |
dc.title | Slow injection of nefopam reduces pain intensity associated with intravenous injection: a prospective randomized trial | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lim, Byung Gun | - |
dc.contributor.affiliatedAuthor | Kim, Heezoo | - |
dc.contributor.affiliatedAuthor | Kong, Myoung Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Mi Kyoung | - |
dc.contributor.affiliatedAuthor | Lee, Il Ok | - |
dc.identifier.doi | 10.1007/s00540-013-1744-z | - |
dc.identifier.scopusid | 2-s2.0-84903582275 | - |
dc.identifier.wosid | 000337791800012 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ANESTHESIA, v.28, no.3, pp.399 - 406 | - |
dc.relation.isPartOf | JOURNAL OF ANESTHESIA | - |
dc.citation.title | JOURNAL OF ANESTHESIA | - |
dc.citation.volume | 28 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 399 | - |
dc.citation.endPage | 406 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Anesthesiology | - |
dc.relation.journalWebOfScienceCategory | Anesthesiology | - |
dc.subject.keywordPlus | POSTOPERATIVE PAIN | - |
dc.subject.keywordPlus | MORPHINE | - |
dc.subject.keywordPlus | MIDAZOLAM | - |
dc.subject.keywordPlus | PROPOFOL | - |
dc.subject.keywordPlus | ANALOG | - |
dc.subject.keywordPlus | KETOPROFEN | - |
dc.subject.keywordPlus | ANALGESIA | - |
dc.subject.keywordPlus | SCALE | - |
dc.subject.keywordAuthor | Intravenous injections | - |
dc.subject.keywordAuthor | Injection pain | - |
dc.subject.keywordAuthor | Nefopam | - |
dc.subject.keywordAuthor | Visual analogue pain scale | - |
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