Meta-Analysis of Associations Between the Peroxisome Proliferator-Activated Receptor-gamma Pro12Ala Polymorphism and Susceptibility to Nonalcoholic Fatty Liver Disease, Rheumatoid Arthritis, and Psoriatic Arthritis
DC Field | Value | Language |
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dc.contributor.author | Lee, Young Ho | - |
dc.contributor.author | Bae, Sang-Cheol | - |
dc.contributor.author | Song, Gwan Gyu | - |
dc.date.accessioned | 2021-09-05T08:58:52Z | - |
dc.date.available | 2021-09-05T08:58:52Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-05-01 | - |
dc.identifier.issn | 1945-0265 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/98556 | - |
dc.description.abstract | Introduction: The purpose of this study was to examine whether a Proline (Pro)-to-Alanine (Ala) exchange at codon 12 (Pro12Ala) polymorphism of the peroxisome proliferator-activated receptor-gamma (PPAR) is associated with susceptibility to nonalcoholic fatty liver disease (NAFLD), rheumatoid arthritis (RA), and psoriatic arthritis (PsA). Methods: A meta-analysis was conducted on the association between the PPAR Pro12Ala polymorphism and NAFLD, RA, and PsA. Results: Nine studies, including five on NAFLD, two on RA, and two on PsA, were available for the meta-analysis consisting of 8082 cases and 3790 controls. The meta-analysis revealed no association between the Ala allele of the PPAR Pro12Ala polymorphism and NAFLD (odds ratios [OR]=0.936, 95% confidence interval [CI]=0.672-1.302, p=0.693). However, stratification by ethnicity indicated an association between the Ala allele and NAFLD in East Asians (OR=0.700, 95% CI=0.496-0.987, p=0.042), but not in Europeans (OR=1.128, 95% CI=0.863-1.475, p=0.378). Analysis using the dominant model showed the same Ala allele pattern in East Asians and Europeans (OR=0.688, 95% CI=0.484-0.978, p=0.037; OR=1.051, 95% CI=0.782-1.413, p=0.742), demonstrating a significant association between the Ala allele and NAFLD in East Asians. The meta-analysis revealed no association between the Ala allele and RA in East Asians (OR=0.467, 95% CI=0.188-1.161, p=0.101), and no association was found between the Ala allele and PsA in Europeans (OR=0.869, 95% CI=0.465-1.627, p=0.662). Conclusions: Our meta-analysis demonstrates that the PPAR Pro12Ala polymorphism is associated with susceptibility to NAFLD in East Asians, but not in European populations. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MARY ANN LIEBERT, INC | - |
dc.subject | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject | GENE POLYMORPHISMS | - |
dc.subject | CHINESE PEOPLE | - |
dc.subject | CONTRIBUTES | - |
dc.subject | ALPHA | - |
dc.subject | PPARG | - |
dc.subject | RISK | - |
dc.subject | MASS | - |
dc.title | Meta-Analysis of Associations Between the Peroxisome Proliferator-Activated Receptor-gamma Pro12Ala Polymorphism and Susceptibility to Nonalcoholic Fatty Liver Disease, Rheumatoid Arthritis, and Psoriatic Arthritis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.identifier.doi | 10.1089/gtmb.2013.0503 | - |
dc.identifier.scopusid | 2-s2.0-84899798690 | - |
dc.identifier.wosid | 000335573600008 | - |
dc.identifier.bibliographicCitation | GENETIC TESTING AND MOLECULAR BIOMARKERS, v.18, no.5, pp.341 - 348 | - |
dc.relation.isPartOf | GENETIC TESTING AND MOLECULAR BIOMARKERS | - |
dc.citation.title | GENETIC TESTING AND MOLECULAR BIOMARKERS | - |
dc.citation.volume | 18 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 341 | - |
dc.citation.endPage | 348 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.subject.keywordPlus | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject.keywordPlus | GENE POLYMORPHISMS | - |
dc.subject.keywordPlus | CHINESE PEOPLE | - |
dc.subject.keywordPlus | CONTRIBUTES | - |
dc.subject.keywordPlus | ALPHA | - |
dc.subject.keywordPlus | PPARG | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | MASS | - |
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