Synthesis of xanthone derivatives based on alpha-mangostin and their biological evaluation for anti-cancer agents
DC Field | Value | Language |
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dc.contributor.author | Fei, Xiang | - |
dc.contributor.author | Jo, Minmi | - |
dc.contributor.author | Lee, Bit | - |
dc.contributor.author | Han, Sang-Bae | - |
dc.contributor.author | Lee, Kiho | - |
dc.contributor.author | Jung, Jae-Kyung | - |
dc.contributor.author | Seo, Seung-Yong | - |
dc.contributor.author | Kwak, Young-Shin | - |
dc.date.accessioned | 2021-09-05T08:58:59Z | - |
dc.date.available | 2021-09-05T08:58:59Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-05-01 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/98557 | - |
dc.description.abstract | A xanthone-derived natural product, alpha-mangostin is isolated from various parts of the mangosteen, Garcinia mangostana L. (Clusiaceae), a well-known tropical fruit. Novel xanthone derivatives based on a-mangostin were synthesized and evaluated as anti-cancer agents by cytotoxicity activity screening using 5 human cancer cell lines. Some of these analogs had potent to moderate inhibitory activities. The structure-activity relationship studies revealed that phenol groups on C3 and C6 are critical to anti-proliferative activity and C4 modification is capable to improve both anti-cancer activity and drug-like properties. Our findings provide new possibilities for further explorations to improve potency. (C) 2014 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | PROSTAGLANDIN E-2 SYNTHESIS | - |
dc.subject | GARCINIA-MANGOSTANA | - |
dc.subject | PRENYLATED XANTHONES | - |
dc.subject | MEDICINAL PROPERTIES | - |
dc.subject | HUMAN LEUKEMIA | - |
dc.subject | CELLS | - |
dc.subject | INHIBITION | - |
dc.subject | PERICARP | - |
dc.subject | ANALOGS | - |
dc.subject | CANCER | - |
dc.title | Synthesis of xanthone derivatives based on alpha-mangostin and their biological evaluation for anti-cancer agents | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Kiho | - |
dc.contributor.affiliatedAuthor | Kwak, Young-Shin | - |
dc.identifier.doi | 10.1016/j.bmcl.2014.03.047 | - |
dc.identifier.scopusid | 2-s2.0-84899062231 | - |
dc.identifier.wosid | 000334337100006 | - |
dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.24, no.9, pp.2062 - 2065 | - |
dc.relation.isPartOf | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.citation.volume | 24 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 2062 | - |
dc.citation.endPage | 2065 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.subject.keywordPlus | PROSTAGLANDIN E-2 SYNTHESIS | - |
dc.subject.keywordPlus | GARCINIA-MANGOSTANA | - |
dc.subject.keywordPlus | PRENYLATED XANTHONES | - |
dc.subject.keywordPlus | MEDICINAL PROPERTIES | - |
dc.subject.keywordPlus | HUMAN LEUKEMIA | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | PERICARP | - |
dc.subject.keywordPlus | ANALOGS | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordAuthor | Xanthone | - |
dc.subject.keywordAuthor | alpha-Mangostin | - |
dc.subject.keywordAuthor | Anti-cancer agent | - |
dc.subject.keywordAuthor | Cytotoxicity | - |
dc.subject.keywordAuthor | Kinetic solubility | - |
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