Clinical Outcomes in Patients with Intermediate Coronary Stenoses: MINIATURE Investigators (Korea MultIceNter TrIal on Long-Term Clinical Outcome According to the Plaque Burden and Treatment Strategy in Lesions with MinimUm Lumen ARea lEss Than 4 mm(2) Using Intravascular Ultrasound)
- Authors
- Hong, Young Joon; Choi, Yun Ha; Park, Soo Young; Nam, Chang Wook; Cho, Jang Hyun; Kang, Won Yu; Lee, Sang Rok; Lee, Sung Yun; Kim, Sang Wook; Lim, Sang Yeob; Yun, Kyung Ho; Kim, Jung Sun; Kim, Jin Won; Kang, Woong Chol; Kim, Ki Seok; Choi, Jin Ho; Chung, Joong Wha; Kim, Soo Joong; Ahn, Youngkeun; Jeong, Myung Ho
- Issue Date
- 5월-2014
- Publisher
- KOREAN SOC CARDIOLOGY
- Keywords
- Coronary artery disease; Atherosclerotic plaque; Intravascular ultrasonography
- Citation
- KOREAN CIRCULATION JOURNAL, v.44, no.3, pp.148 - 155
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- KOREAN CIRCULATION JOURNAL
- Volume
- 44
- Number
- 3
- Start Page
- 148
- End Page
- 155
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/98633
- DOI
- 10.4070/kcj.2014.44.3.148
- ISSN
- 1738-5520
- Abstract
- Background and Objectives: We evaluated the two-year clinical outcomes in patients with angiographically intermediate lesions according to the plaque burden and treatment strategy. Subjects and Methods: We prospectively enrolled patients with angiographically intermediate lesions (diameter stenosis 30-70%) with an intravascular ultrasound (IVUS) minimum lumen area (MLA) <4 mm(2) with 50-70% plaque burden of 16 Korean percutaneous coronary intervention centers. Patients were divided into medical therapy group (n=85) and zotarolimus-eluting stent group (ZES; Resolute) group (n=74). We evaluated the incidences of two-year major adverse cardiovascular events (MACE). Results: A two-year clinical follow-up was completed in 143 patients and MACE occurred in 12 patients. There were no significant differences in the incidences of death (1.3% vs. 3.0%, p=0.471), target vessel-related non-fatal myocardial infarction (0.0% vs. 0.0%, p=1.000) and target vessel revascularizations (7.8% vs. 4.5%, p=0.425) between medical and ZES groups. Independent predictors of two-year MACE included acute myocardial infarction {odds ratio (OR)=2.87; 95% confidence interval (CI) 1.43-6.12, p=0.014}, diabetes mellitus (OR=2.46; 95% CI 1.24-5.56, p=0.028) and non-statin therapy (OR=2.32; 95% CI 1.18-5.24, p=0.034). Conclusion: Medical therapy shows comparable results with ZES, and myocardial infarction, diabetes mellitus and non-statin therapy were associated with the occurrence of two-year MACE in patients with intermediate lesion with IVUS MLA <4 mm(2) with 50-70% of plaque burden.
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