Determination of 2-(3-Benzoyl)-4-Hydroxy-1,1-Dioxo-2H-1,2-Benzothiazine-2-yl-1-Phenylethanone by Liquid Chromatography-Tandem Mass Spectrometry
DC Field | Value | Language |
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dc.contributor.author | Zheng, Zhi | - |
dc.contributor.author | Song, Jin Sook | - |
dc.contributor.author | Lee, Byung Hoi | - |
dc.contributor.author | Ahn, Sung-Hoon | - |
dc.contributor.author | Ahn, Jin-Hee | - |
dc.contributor.author | Woo, JaeChun | - |
dc.contributor.author | Park, Ji-Young | - |
dc.contributor.author | Yoo, Dae Seok | - |
dc.contributor.author | Bae, Myung Ae | - |
dc.date.accessioned | 2021-09-05T09:15:50Z | - |
dc.date.available | 2021-09-05T09:15:50Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-05 | - |
dc.identifier.issn | 0021-9665 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/98671 | - |
dc.description.abstract | 2-(3-Benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone (KR-66344), a 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) inhibitor, is newly developed for the control of type 2 diabetes mellitus (T2DM) and metabolic syndrome. A method for the determination of KR-66344 in rat plasma was developed by liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS-MS) to evaluate the pharmacokinetics of KR-66344. Plasma samples were processed by a liquid-liquid extraction method with ethyl acetate and introduced onto the LC-MS-MS system. The analyte and imipramine (internal standard) were analyzed by multiple reaction monitoring based on transitions at m/z 420.1 -> 105.0 and 282.2 -> 86.0, respectively. The calibration curve was linear (r = 0.9993) over the concentration range of 1.0-1,000 ng/mL. The mean recovery values for KR-66344 and imipramine were 83.8 and 86.2%, respectively. The mean inter-day and intra-day assay precision values were 3.9 and 2.4%, respectively. KR-66344 was stable under various handling and storage conditions. This developed method was applied to a pharmacokinetic study after the oral administration of KR-66344 in rats. The concentration of KR-66344 was readily measurable in rat plasma up to 24 h post-dose after an oral administration, suggesting that current assay is applicable to pharmacokinetic studies for KR-66344. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS INC | - |
dc.subject | DEHYDROGENASE TYPE-1 INHIBITOR | - |
dc.subject | METABOLIC SYNDROME | - |
dc.subject | VISCERAL OBESITY | - |
dc.subject | MICE | - |
dc.subject | SENSITIVITY | - |
dc.title | Determination of 2-(3-Benzoyl)-4-Hydroxy-1,1-Dioxo-2H-1,2-Benzothiazine-2-yl-1-Phenylethanone by Liquid Chromatography-Tandem Mass Spectrometry | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Ji-Young | - |
dc.identifier.doi | 10.1093/chromsci/bmt050 | - |
dc.identifier.scopusid | 2-s2.0-84898863968 | - |
dc.identifier.wosid | 000342734600006 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CHROMATOGRAPHIC SCIENCE, v.52, no.5, pp.406 - 412 | - |
dc.relation.isPartOf | JOURNAL OF CHROMATOGRAPHIC SCIENCE | - |
dc.citation.title | JOURNAL OF CHROMATOGRAPHIC SCIENCE | - |
dc.citation.volume | 52 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 406 | - |
dc.citation.endPage | 412 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemical Research Methods | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Analytical | - |
dc.subject.keywordPlus | DEHYDROGENASE TYPE-1 INHIBITOR | - |
dc.subject.keywordPlus | METABOLIC SYNDROME | - |
dc.subject.keywordPlus | VISCERAL OBESITY | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | SENSITIVITY | - |
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