Toxic effects of silver nanoparticles and nanowires on erythrocyte rheology
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Min Jung | - |
dc.contributor.author | Shin, Sehyun | - |
dc.date.accessioned | 2021-09-05T09:20:21Z | - |
dc.date.available | 2021-09-05T09:20:21Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-05 | - |
dc.identifier.issn | 0278-6915 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/98703 | - |
dc.description.abstract | Rapid developments in the food applications of silver nanomaterials (Ag-NMs) have resulted in concerns related to the risk of overexposure of human blood. We investigated the effect of size and aspect ratio of Ag-NMs on theological characteristics of human erythrocytes, including hemolysis, deformability, aggregation, and morphological changes. Red blood cells (RBCs) were exposed to two different sizes of spherical particles (d similar to 30 nm or 100 nm) or nanowires (d similar to 40 nm, 1-21 mu m in length) at a range of concentrations and incubation times. The concentrations of Ag-NMs were carefully chosen to avoid any hemorheological alteration due to hemolysis. Rheological properties were measured using microfluidic-laser diffractometry and aggregometry. RBC deformability apparently decreased after treatment with a low concentration of Ag-NPs for a short exposure time. However, RBC aggregation was significantly altered after treatment with a low concentration of either Ag-NWs or large Ag-NPs compared to small Ag-NPs. Additional experiments with Ag ions confirmed that the observed rheological changes were mainly caused by the Ag-NMs rather than the Ag ions. These hemorheological findings provide a better understanding of the interaction between RBCs and Ag-NMs and will help in assessing the risk of nanomaterial toxicity in blood. (C) 2014 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | DEFORMABILITY | - |
dc.subject | TRANSLOCATION | - |
dc.subject | NANOMATERIALS | - |
dc.subject | AGGREGATION | - |
dc.subject | MECHANISMS | - |
dc.subject | FINE | - |
dc.title | Toxic effects of silver nanoparticles and nanowires on erythrocyte rheology | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shin, Sehyun | - |
dc.identifier.doi | 10.1016/j.fct.2014.02.006 | - |
dc.identifier.scopusid | 2-s2.0-84896082457 | - |
dc.identifier.wosid | 000336011000010 | - |
dc.identifier.bibliographicCitation | FOOD AND CHEMICAL TOXICOLOGY, v.67, pp.80 - 86 | - |
dc.relation.isPartOf | FOOD AND CHEMICAL TOXICOLOGY | - |
dc.citation.title | FOOD AND CHEMICAL TOXICOLOGY | - |
dc.citation.volume | 67 | - |
dc.citation.startPage | 80 | - |
dc.citation.endPage | 86 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.subject.keywordPlus | DEFORMABILITY | - |
dc.subject.keywordPlus | TRANSLOCATION | - |
dc.subject.keywordPlus | NANOMATERIALS | - |
dc.subject.keywordPlus | AGGREGATION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | FINE | - |
dc.subject.keywordAuthor | Silver nanoparticles | - |
dc.subject.keywordAuthor | Silver nanowires | - |
dc.subject.keywordAuthor | Blood | - |
dc.subject.keywordAuthor | Toxicology | - |
dc.subject.keywordAuthor | Hemorheology | - |
dc.subject.keywordAuthor | Deformability | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.