Synthesis of Multifunctional Fe3O4-CdSe/ZnS Nanoclusters Coated with Lipid A toward Dendritic Cell-Based Immunotherapy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeong, Jinhoo | - |
dc.contributor.author | Kwon, Eun-Kyung | - |
dc.contributor.author | Cheong, Taek-Chin | - |
dc.contributor.author | Park, Heeyeon | - |
dc.contributor.author | Cho, Nam-Hyuk | - |
dc.contributor.author | Kim, Woong | - |
dc.date.accessioned | 2021-09-05T09:37:48Z | - |
dc.date.available | 2021-09-05T09:37:48Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-04-09 | - |
dc.identifier.issn | 1944-8244 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/98772 | - |
dc.description.abstract | We demonstrate a novel route to synthesize Fe3O4-CdSe/ZnS multifunctional nanoclusters (MNCs) with excellent optical and magnetic properties and biocompatibility. The successful fabrication of highly fluorescent and magnetic MNCs is achieved via a coupling process based on a partial ligand exchange reaction at the aqueous-organic solution interface. In addition, we show that dendritic cells (DCs), the sentinel of the immune system, can uptake the MNCs without significant change in cell viability. The MNCs uptaken by the DCs can be used for imaging, tracking, and separating the DCs. Furthermore, the MNCs can be loaded with a pathogen-associated molecular pattern, lipid A, via a hydrophobic-hydrophobic interaction. Ea vivo labeling of DCs with the MNC-lipid A complex enhances the DC migration to draining lymph nodes and tumor antigen-specific T cell responses in vivo. Our work may contribute to the development of synthetic routes to various multifunctional nanoclusters and DC-based cancer immunotherapies. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | IN-VIVO | - |
dc.subject | QUANTUM DOTS | - |
dc.subject | CANCER-IMMUNOTHERAPY | - |
dc.subject | MAGNETIC NANOPARTICLES | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | IMMUNITY | - |
dc.subject | ANTIGEN | - |
dc.subject | TOLL-LIKE-RECEPTOR-4 | - |
dc.subject | MICROSPHERES | - |
dc.subject | MIGRATION | - |
dc.title | Synthesis of Multifunctional Fe3O4-CdSe/ZnS Nanoclusters Coated with Lipid A toward Dendritic Cell-Based Immunotherapy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Woong | - |
dc.identifier.doi | 10.1021/am500661j | - |
dc.identifier.scopusid | 2-s2.0-84898422285 | - |
dc.identifier.wosid | 000334572800087 | - |
dc.identifier.bibliographicCitation | ACS APPLIED MATERIALS & INTERFACES, v.6, no.7, pp.5297 - 5307 | - |
dc.relation.isPartOf | ACS APPLIED MATERIALS & INTERFACES | - |
dc.citation.title | ACS APPLIED MATERIALS & INTERFACES | - |
dc.citation.volume | 6 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 5297 | - |
dc.citation.endPage | 5307 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | QUANTUM DOTS | - |
dc.subject.keywordPlus | CANCER-IMMUNOTHERAPY | - |
dc.subject.keywordPlus | MAGNETIC NANOPARTICLES | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | IMMUNITY | - |
dc.subject.keywordPlus | ANTIGEN | - |
dc.subject.keywordPlus | TOLL-LIKE-RECEPTOR-4 | - |
dc.subject.keywordPlus | MICROSPHERES | - |
dc.subject.keywordPlus | MIGRATION | - |
dc.subject.keywordAuthor | multifunctional | - |
dc.subject.keywordAuthor | nanocluster | - |
dc.subject.keywordAuthor | fluorescent | - |
dc.subject.keywordAuthor | superparamagnetic | - |
dc.subject.keywordAuthor | dendritic cell | - |
dc.subject.keywordAuthor | T cell | - |
dc.subject.keywordAuthor | immunotherapy | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.